grant
Defining the Mechanisms of Temperature Sensitive Meiotic Chromosome Structures in Male Infertility
Organization COLORADO STATE UNIVERSITYLocation FORT COLLINS, UNITED STATESPosted 1 Apr 2025Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026Aberrant ChromosomeAblationAddressAffectBiologic ModelsBiological ModelsBirth DefectsBody TemperatureC elegansC. elegansC.elegansCaenorhabditis elegansCancersCannot achieve a pregnancyCell NucleusChromosomal AberrationsChromosomal AbnormalitiesChromosomal AlterationsChromosomal OrganizationChromosomal StructureChromosome AberrationsChromosome AlterationsChromosome AnomaliesChromosome OrganizationChromosome StructuresChromosome abnormalityChromosomesComparative StudyCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationCytogenetic AberrationsCytogenetic AbnormalitiesDNA DamageDNA InjuryDNA RecombinationDNA mutationDataDefectDevelopmental ProcessDifferences between sexesDiffers between sexesDifficulty conceivingExhibitsExposure toExpression SignatureFailureFecundabilityFecundityFertilityFertility DisordersFoundationsGametesGene Expression ProfileGeneHomologGenerationsGenetic ChangeGenetic RecombinationGenetic defectGenetic mutationGenomeGermGerm CellsGerm-Line CellsGoalsHaploidHaploidyHeat StressHomologHomologous GeneHomologueHumanInfertilityLinkMale InfertilityMale reproductive healthMalignant NeoplasmsMalignant Testicular NeoplasmMalignant Testicular TumorMalignant TumorMalignant Tumor of the TestisMalignant neoplasm of testisMammaliaMammalsMeiosisMeiotic Prophase IMiceMice MammalsMiscarriageModel SystemModern ManMolecularMurineMusMutationNatureNucleusOocytesOogenesisOrganismOutcomeOvocytesPhenotypePredispositionProcessProphase IProtein DynamicsProteinsProteomicsRecombinationReproductionReproductive CellsResistanceRiskRoleSex CellSex DifferencesSexual differencesSpermSpermatocytesSpermatogenesisSpermatozoaSpermiocytesSpontaneous abortionStressStructureSusceptibilitySynaptonemal ComplexTemperatureTesticular CancerTestis CancerTransmissionVisualizationWorkbasal bodybiological adaptation to stresscancer riskchromosomal defectchromosome defecteggexperienceexperimentexperimental researchexperimental studyexperimentsfertility cessationfertility defectfertility lossgene expression patterngene expression signaturegenetic informationgenome integritygenome mutationgenomic integrityinfertileinfertile malesinfertile meninfertility in meninitial cellinsightkinetosomeliving systemmale factor infertilitymale fertilitymale germ cellsmale reproductive functionsmale reproductive tract healthmalignancymeioticmen facing infertilitymen with infertilitymens reproductive functionsmens reproductive healthmicroscope imagingmicroscopic imagingmicroscopy imagingneoplasm/cancernext generationnovelprotein complexreaction; crisisreproductive health in menresistantresponsesexsex based differencessex dimorphismsex-dependent differencessex-related differencessex-specific differencessexual cellsexual dimorphismsexually dimorphicsocial rolesperm cellstress responsestress; reactiontranscriptional profiletranscriptional signaturetransmission processzoosperm
Description preview
PROJECT SUMMARY
Sexually reproducing organisms faithfully transmit their genome to the next generation via haploid gametes,
such as eggs and sperm. In contrast to oogenesis and other developmental processes, spermatogenesis must
occur 2-7ºC below basal body temperature. Failure to precisely thermoregulate spermatogenesis or exposure
to elevated…
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