grant
Defining the mechanism of CNS inflammation induced by colitis
Organization LOYOLA UNIVERSITY CHICAGOLocation MAYWOOD, UNITED STATESPosted 2 Feb 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AcuteAffectAmentiaAmericanAnimalsAnxietyApoptosis-Related Cysteine Protease Caspase 1AstrocytesAstrocytusAstrogliaAutomobile DrivingBioluminescenceBiosensorBloodBlood Reticuloendothelial SystemBlood SerumBody SystemBody TissuesBrainBrain Nervous SystemCASP-1CASP1CASP1 geneCNS Nervous SystemCaspase-1Caspase-1 GeneCell BodyCell Communication and SignalingCell LineageCell SignalingCellsCentral Nervous SystemCephalicCirculationCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalColitisColonColonic inflammationCranialCrohn diseaseCrohn'sCrohn's diseaseCrohn's disorderDSS colitisDSS modelDSS mouse modelDSS-induced acute colitisDSS-induced colitisDataDegenerative Neurologic DisordersDementiaDiseaseDisease remissionDisorderDisturbance in cognitionDysfunctionEncephalonEndothelial CellsExhibitsFlareFunctional disorderGene TranscriptionGenetic TranscriptionGoalsGrantGranulomatous EnteritisGvHDHIV InfectionsHIV viral infectionHIV virus infectionHIV-1 infectionHomologous Wasting DiseaseHortega cellICE ProteaseIL-1 beta ConvertaseIL-1 beta-Converting EnzymeIL-1BCIL-1b Converting EnzymeIL1B-ConvertaseIL1BCIL1BCEImpaired cognitionIndividualInfection by HIV-1Infection from HIV-1Infection of HIV-1InflammasomeInflammationInflammation MediatorsInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderInflammatory ResponseInterleukin 1-B Converting EnzymeInterleukin 1-Beta ConvertaseInterleukin-1 Beta Converting EnzymeInterleukin-1 Converting EnzymeIntracellular Communication and SignalingKnowledgeLinkLipidsLuciferase ImmunologicLuciferasesMTBIMediatingMediatorMental DepressionMiceMice MammalsMicrogliaModelingMolecularMolecular Sieve ChromatographyMonitorMurineMusNatureNerve CellsNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeuraxisNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologicNeurologic Degenerative ConditionsNeurologicalNeuronsOnset of illnessOrgan SystemParalysis AgitansParkinsonParkinson DiseasePathogenesisPathologyPatientsPatternPhysiopathologyPopulationPredispositionPrimary ParkinsonismProteinsRNA ExpressionRemissionReporterResolutionRiskRunt DiseaseS. aureus infectionSerumSignal TransductionSignal Transduction SystemsSignalingSize Exclusion ChromatographySodium Dextran SulfateStaph aureus infectionStaphylococcus aureus infectionSusceptibilitySystemTestingTherapeuticTherapeutic InterventionTissuesTranscriptionUlcerated ColitisUlcerative Colitisastrocytic gliabiological sensorbiological signal transductionbowel inflammationcell typeco-morbidco-morbiditycognitive dysfunctioncognitive losscolitis-induced dysbiosiscomorbiditycytokinedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdepressiondextran sulfate sodium colitisdextran sulfate sodium induced colitisdextran sulfate sodium modeldextran sulfate sodium mouse modeldietarydisease onsetdisorder onsetdrivingeleocolitisexperimentexperimental researchexperimental studyexperimentsgitter cellgraft versus host diseasegraft vs host diseasegraft vs. host diseasegut inflammationhuman diseasehuman immunodeficiency virus infectionhuman modelimprovedin vivoin vivo monitoringinfected with HIVinfected with S. aureusinfected with Staph aureusinfected with Staphylococcus aureusinfected with human immunodeficiency virusinflamed bowelinflamed coloninflamed gutinflamed intestineinflammatory disease of the intestineinflammatory disorder of the intestineinflammatory mediatorintervention therapyintestinal autoinflammationintestinal barrierintestinal inflammationintestinal mucosal barriermesogliamicrobialmicrobial productsmicroglial cellmicrogliocytemild TBImild brain traumamild traumatic brain injurymodel of humanmouse modelmurine modelneural inflammationneurodegenerative illnessneuroinflammationneuroinflammatoryneuronalnovelpathogenpathophysiologyperivascular glial cellpreventpreventingregional enteritisresolutionsresponsesystemic inflammationsystemic inflammatory responsetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatment
Description preview
Inflammatory Bowel Diseases (IBD), including Crohn's disease (CD) and ulcerative
colitis (UC), are life-long diseases characterized by cycles of active flares and
remission. Disease flares result in significant inflammation in the colon, as well as
pathology in other organ systems, including the brain. Central nervous system (CNS)
dysfunction is a…
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