grant
Defining the landscape of bacterial-colonized microniches in tumors and their role in intratumoral heterogeneity.
Organization UNIVERSITY OF TX MD ANDERSON CAN CTRLocation HOUSTON, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025Anaerobic BacteriaAnimal ModelAnimal Models and Related StudiesAreaBacteriaBiologic ModelsBiological ModelsBlood NeutrophilBlood Polymorphonuclear NeutrophilBody TissuesBystander EffectC fusiformeC. fusiformeCD152CD152 AntigenCD152 GeneCTLA 4CTLA-4 GeneCTLA4CTLA4 geneCTLA4-TMCancer BiologyCancer TreatmentCancersCell BodyCell FunctionCell PhysiologyCell ProcessCell SurvivalCell ViabilityCellsCellular FunctionCellular Immune FunctionCellular PhysiologyCellular ProcessCollectionColorectal CancerColorectal NeoplasmsColorectal TumorsComplexCorynebacterium fusiformeCytotoxic T-Lymphocyte Protein 4Cytotoxic T-Lymphocyte-Associated Antigen 4Cytotoxic T-Lymphocyte-Associated Protein 4Cytotoxic T-Lymphocyte-Associated Serine Esterase-4DataDigestive Tract TumorDigestive TumorDisease ProgressionEcologic SystemsEcological SystemsEcosystemEndothelial CellsEnvironmentEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiology ResearchExclusionF fusiformisF nucleatumF nucleatusF. fusiformisF. nucleatumF. nucleatusFibroblastsFusiformis fusiformisFusiformis nucleatusFusobacterium nucleatumGI NeoplasmGI Tract TumorGI TumorGI cancersGI malignanciesGI tract cancersGastrointestinal CancerGastrointestinal NeoplasmsGastrointestinal Tract CancerGastrointestinal Tract TumorGastrointestinal TumorGene TranscriptionGenetic TranscriptionGerm-FreeGoalsHost FactorHost Factor ProteinHumanImmuneImmune EvasionImmune infiltratesImmunesImmunomodulationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIn SituInfiltrationIntegration Host FactorsIntratumoral heterogeneityInvadedKnowledgeLarge Bowel TumorLarge Intestine NeoplasmLarge Intestine TumorMacrophageMalignant CellMalignant Gastrointestinal NeoplasmMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant Oral Cavity NeoplasmMalignant Oral Cavity TumorMalignant Oral NeoplasmMalignant TumorMalignant neoplasm of gastrointestinal tractMapsMarrow NeutrophilMediatingMetabolicMicrobeMicrobiomicsModel SystemModern ManMolecular AnalysisMouth CancerMyeloid CellsMφNeoplasm of the Digestive TractNeoplasm of the GI TractNeoplasm of the Gastrointestinal TractNeutrophilic GranulocyteNeutrophilic LeukocyteNon-MalignantNormal TissueNormal tissue morphologyNutrientOral CancerOral Cavity Squamous Cell CarcinomaOral squamous cell carcinomaPD 1PD-1PD1PatientsPhenotypePolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationPredispositionProductionProteinsRNA ExpressionRecurrent diseaseRelapsed DiseaseResistanceResolutionRoleShapesSolidSpatial DistributionSubcellular ProcessSusceptibilityT cell infiltrationT-CellsT-LymphocyteTechnologyTestingTissuesTranscriptionTumor TissueTumor-infiltrating immune cellsUpregulationVascularizationWorkanaerobeanalyze microbiomeanti-cancer therapybacterial communitycancer cellcancer microenvironmentcancer progressioncancer therapycancer typecancer-directed therapycell typecolorectal neoplasiacomparativecytokinecytotoxic T-lymphocyte antigen 4digestive neoplasmepidemiologic investigationepidemiology studyexperiencegastrointestinal malignanciesheterogeneity in tumorshost microbe associationhost microbe relationshiphost microbiotahost microflorahost-microbe interactionshost-microbial interactionshost-microorganism interactionsimmune cell infiltrateimmune cell infiltration of tumorsimmune cells infiltrating the tumorimmune cells that infiltrate the tumorimmune check pointimmune checkpointimmune evasiveimmune functionimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmunecheckpointimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunosuppressive activityimmunosuppressive functionimmunosuppressive responsein vivoinfiltration of tumors by immune cellsinnovateinnovationinnovativeinsightintra-tumoral heterogeneityintratumor heterogeneityintratumoral immune cellintratumoral immune infiltratelarge bowel neoplasmmalignancymalignant mouth neoplasmmalignant mouth tumormetabolism measurementmetabolomicsmetabonomicsmicrobialmicrobial consortiamicrobial floramicrobiome analysismicrobiome researchmicrobiome sciencemicrobiome studiesmicrobiotamicrofloramodel of animalmouse modelmouth SCCmouth squamous cell carcinomamultiomicsmultiple omicsmultispecies consortiamurine modelneoplasm progressionneoplasm/cancerneoplastic progressionneutrophilnew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnonmalignantnovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapyoral cavity SCCoral cavity canceroral squamous canceroral squamous carcinomapanomicspathogenpermissivenesspreventpreventingprogrammed cell death 1programmed cell death protein 1programmed death 1programsrecruitresident microbesresident microfloraresistance to therapyresistantresistant to therapyresolutionsscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsle2social rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial multiomicsspatial omicsspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatial tri-omicsspatially resolved transcriptomicsspatio transcriptomicssystemic lupus erythematosus susceptibility 2therapeutic resistancetherapy resistantthymus derived lymphocytetreatment resistancetumortumor heterogeneitytumor immune celltumor immune infiltratetumor infiltration of immune cellstumor microenvironmenttumor progression
Description preview
PROJECT SUMMARY/ABSTRACT
Within a patient’s tumor, malignant cells are surround by a complex and dynamic collection of cell types, which
includes the intratumoral microbiota. However, there is a fundamental lack of understanding on how microbes
within the tumor microenvironment (TME) interact with human components of the tumor, or how they might…
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