grant
Defining the Innate Immune Cell Profile of Factor VIII Immunity
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 18 Apr 2025Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAb responseAcuteAddressAdolescentAdolescent YouthAdultAdult HumanAffectAgeAlternative TherapiesAlternative interventionAntibodiesAntibody FormationAntibody ProductionAntibody titer measurementAntihemophilic FactorB blood cellsB cellB cellsB-Cell ActivationB-CellsB-LymphocytesB-cellBleedingBlood Coagulation Factor VIIICD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCaringCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessChildChild YouthChildhoodChildren (0-21)ClottingCoagulationCoagulation Factor VIIICoagulation Factor VIIIcCoagulation ProcessComplicationCytokine Signal TransductionCytokine SignalingDataDendritic CellsDendritic cell activationDevelopmentDifferential Gene ExpressionDiseaseDisorderDoseEdodekin AlfaEventExposure toFactor VIIIFactor VIII DeficiencyFactor VIII F8BFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFosteringGenesGenomicsGoalsHemophiliaHemophilia AHemorrhageHemostatic AgentsHemostaticsIFNIFN-GammaIFN-gIFN-γIFNGIFNγIL-12IL12ImmuneImmune InterferonImmune Modulation TherapyImmune ToleranceImmune responseImmunesImmunityImmunizeImmunochemical ImmunologicImmunologicImmunologic ToleranceImmunologicalImmunologicallyImmunologicsIndividualInfantInflammatoryInfusionInfusion proceduresInjectionsInjuryInnate Immune ResponseInnovative TherapyInterferon GammaInterferon ReceptorInterferon Type IIInterferonsInterleukin-12Intracellular Communication and SignalingIntracellular MembranesIntravenousKO miceKnock-out MiceKnockout MiceLifeMediatingMediatorMethodsMiceMice MammalsModernizationMorbidityMorbidity - disease rateMurineMusNKSFNatural Killer Cell Stimulatory FactorNull MouseOperative ProceduresOperative Surgical ProceduresPBMCPatientsPeripheralPeripheral Blood Mononuclear CellPersonsPhagocytesPhagocytic CellPreventative strategyPreventionPrevention strategyPreventive strategyProcessProcoagulant ComponentProductionProphylactic treatmentProphylaxisProteinsQOLQuality of lifeReceptor GeneRegulator GenesRelapseResearchSamplingSchool-Age PopulationSignal TransductionSignal Transduction SystemsSignalingSourceSpleenSpleen Reticuloendothelial SystemSubcellular ProcessSurgicalSurgical InterventionsSurgical ProcedureT cell differentiationT-Cell ActivationT4 CellsT4 LymphocytesTestingTherapeuticThromboplastinogenTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionToddlerTranscriptional Regulatory ElementsTreatment ProtocolsTreatment RegimenTreatment ScheduleUpregulationVeiled CellsWorkactivate T cellsactivated B cellsadaptive immunityadulthoodage groupagesamebocyteantibody biosynthesisantibody titeringantihemophilic factor Abiological signal transductionblood losscohortcomplex Blood-coagulation factor VIIIcytokinedevelopmentalexperienceflow cytophotometrygenetic trans acting elementglobal gene expressionglobal transcription profilehost responseimmune modulatory therapiesimmune modulatory treatmentimmune regulation therapyimmune regulation treatmentimmune regulatory therapyimmune system responseimmune system toleranceimmune unresponsivenessimmune-modulation treatmentimmunoglobulin biosynthesisimmunological paralysisimmunomodulation therapyimmunomodulation treatmentimmunomodulator therapiesimmunomodulator treatmentimmunomodulator-based therapiesimmunomodulatory biologicsimmunomodulatory therapiesimmunomodulatory treatmentimmunoregulatory therapyimmunoregulatory treatmentimmunoresponseinfusionsinhibitorinjuriesinnovateinnovationinnovativeinsightisolated individualsisolated peoplejuvenilejuvenile humankidslFN-Gammalife spanlifespanlonely individualslonely peoplemembrane assemblymortalitymouse modelmurine modelneutralizing antibodynovelpediatricperipheral tolerancepharmacologicplatelet cofactor Ipreventpreventingregulatory generesponsescRNA sequencingscRNA-seqschool agesingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingstemsurgerytherapeutic immunomodulationtherapeutic immunoregulationtherapeutic targetthromboplastinogen Atooltraffickingtrans acting elementtranscriptometranscriptomicsyoungster
Description preview
PROJECT SUMMARY
The development of inhibitors (i.e., neutralizing antibodies) against infused coagulation protein factor VIII
(FVIII) is the most significant treatment-related complication in modern hemophilia A care. Administration of
frequent and high doses of FVIII over months-years, referred to as immune tolerance induction, remains the…
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