grant
Defining the impact of cannabinoids on the HIV reservoir in humanized mice
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 30 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAcuteAddressAffectAgonistAnimal ModelAnimal Models and Related StudiesAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAssayAutoregulationBioassayBiological AssayBiologyBloodBlood Reticuloendothelial SystemBody TissuesBrainBrain Nervous SystemCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCannabinoidsCannabisCell BodyCellsCharacteristicsChronicClinicalCytotoxic cellDataDoseEffector CellEncephalonEventExhibitsExposure toGene TranscriptionGenetic TranscriptionGoalsHIVHIV InfectionsHTLV-III InfectionsHTLV-III-LAV InfectionsHeterogeneityHomeostasisHortega cellHumanHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsImmuneImmune MarkersImmune responseImmune systemImmunesImmunityImmunochemical ImmunologicImmunoglobulin Enhancer-Binding ProteinImmunologicImmunologic MarkersImmunologicalImmunologicallyImmunologicsImmunomodulationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIndividualInfectionInflammationInflammatoryK lymphocyteLAV-HTLV-IIILearningLymphadenopathy-Associated VirusMaintenanceMediatingMethodsMiceMice MammalsMicrogliaModelingModern ManMolecularMurineMusNF-kBNF-kappa BNF-kappaBNFKBNK CellsNatural Killer CellsNuclear Factor kappa BNuclear Transcription Factor NF-kBOutcomeParticipantPathway interactionsPeripheralPersonsPhasePhenotypePhysiological HomeostasisPopulationRNA ExpressionRNA SeqRNA sequencingRNAseqResearchSignal InductionSignal PathwaySolidSpleenSpleen Reticuloendothelial SystemT-CellsT-LymphocyteT4 CellsT4 LymphocytesTHC co-useTHC exposureTHC useTestingTetrahydrocannabinol co-useTetrahydrocannabinol useTissue SampleTissuesTranscriptionTranscription Factor NF-kBViralViral ActivityViral FunctionViral LatencyViral PhysiologyViral reservoirViremiaVirus LatencyVirus reservoirVirus-HIVWorkantiretroviral therapyantiretroviral treatmentbrain tissuecannabinoid receptorcannabis usecannabis usercytokineexhaustiongitter cellhost responsehuman datahuman tissuehumanized micehumanized mouseimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmune-based biomarkersimmunologic reactivity controlimmunological biomarkersimmunological markersimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responsein vivoinnovateinnovationinnovativeinsightkappa B Enhancer Binding Proteinlatent HIV reservoirlatent HIV-1 reservoirlatent HIV1 reservoirlongitudinal human studymarijuana usemarijuana usermesogliamicroglial cellmicrogliocytemodel of animalmolecular phenotypemouse modelmultiple substance usemultisubstance usemurine modelneuroprotectionneuroprotectivenovelnuclear factor kappa betapathwayperipheral bloodperivascular glial cellpoly substance usepolysubstance usereconstitutereconstitutionscATAC sequencingscATAC-seqsenescencesenescentsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell analysissingle cell sequencing assay for transposase accessible chromatinsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqtetrahydrocannabinol exposurethymus derived lymphocytetooltranscriptome sequencingtranscriptomic sequencingviraemiaviral DNAviral RNAviral sepsisvirus DNAvirus RNAvirusemia
Description preview
Abstract
Cannabis (CB) use is prevalent amongst people with HIV (PWH) but its impact on HIV infection and the latent
viral reservoir has not been fully examined. In particular, the impact of CB on the HIV reservoir in solid tissues
such as the brain is completely unknown. As such, animal models in which dosing can be carefully controlled
and…
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