grant
Defining Protective IgGs to Food Allergy
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY202521+ years old7S Gamma GlobulinAdultAdult HumanAdverse reactionsAffectAffinityAllergensAllergic to foodAllergy to foodAllergy to peanutsAnaphylactic ReactionAnaphylactic ShockAnaphylaxisAntibodiesAntigen-Antibody ComplexB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBasophilic GranulocyteBasophilsBindingBiochemistryBiological AgentBiological ChemistryBiological MarkersBiological ProductsBiologyBiophysicsBlood BasophilBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood SerumCashewCashew nutCell BodyCellsCellular ImmunologyCharacteristicsClinicClinical EvaluationClinical TestingClinical TrialsCountryDendritic CellsDevelopmentDiseaseDisorderDoseDropsFoodFood AllergyFood HypersensitivityGlycansGlycobiologyGoalsGroundnut HypersensitivityHuman EngineeringIgEIgGIgG2IgG4ImmuneImmune ComplexImmunesImmunoglobulin EImmunoglobulin GImmunologyIndividualKnowledgeMacrophageMaintenanceMarrow Mast CellMarrow NeutrophilMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMetabolic GlycosylationMiceMice MammalsMissionModelingMolecularMolecular ImmunologyMolecular InteractionMurineMusMφNational Institutes of HealthNeutrophilic GranulocyteNeutrophilic LeukocyteOralOral CharactersOutcomePathway interactionsPatientsPatternPeanut HypersensitivityPhenotypePolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPolysaccharidesPopulationProteinsPublic HealthRegulatory T-LymphocyteResearchRoleRouteSafetySamplingSerumShellfishSpecificityTemperatureTestingTherapeuticTissue BasophilsTractionTreatment FailureTreatment ProtocolsTreatment RegimenTreatment ScheduleTregUnited States National Institutes of HealthVeiled Cellsadulthoodage groupallergic reaction to peanutallergic response to peanutallergic to peanutsanaphylactic response to foodanaphylaxis caused by foodanaphylaxis due to foodanaphylaxis to foodbio-markersbiologic markerbiologicsbiomarkerbiomarker discoverybiomarker identificationbiopharmaceuticalbiophysical foundationbiophysical principlesbiophysical sciencesbiotherapeutic agentclinical testdesensitizationdevelopmentalfeedingfood allergenfood allergy anaphylaxisfood anaphylactic reactionfood anaphylaxisfood associated anaphylaxisfood induced anaphylaxisfood mediated anaphylaxisfood protectionfood related anaphylaxisfood supply protectionfood triggered anaphylaxisglycosylated IgGglycosylated immunoglobulin Gglycosylationidentification of biomarkersidentification of new biomarkersimmunotherapy trialsmarker identificationmast cellmastocytemouse modelmurine modelneutrophilnew markernovelnovel biomarkernovel markeromalizumaboral immunotherapyoutcome predictionpathwaypeanut allergicpeanut allergypredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerprospectiveregulatory T-cellsresearch clinical testingresponsesocial roletherapy failuretranslational impact
Description preview
Project Summary/Abstract
Approximately 2% of the population of Western country is affected by peanut allergies. Peanut oral
immunotherapy OIT has gained traction in the clinic as therapeutic option. However, successful peanut OIT
resulting in tolerance to peanuts, or sustained unresponsiveness, occurs in only 50% of treated individuals. It is
not…
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