grant
DEFINING MECHANISMS OF PROGENITOR BALANCE AND NEURONAL CONNECTIVITY
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 1 May 2020Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025ASDAutismAutistic DisorderCell Communication and SignalingCell SignalingCerebral cortexCiliaCortical MalformationDNA mutationDevelopmentDevelopmental ProcessDiagnosticEarly Infantile AutismEpilepsyEpileptic SeizuresEpilepticsEquilibriumEvaluationFoundationsGeneralized GrowthGenerationsGenetic ChangeGenetic ModelsGenetic defectGenetic mutationGoalsGrowthHumanImageInfantile AutismIntracellular Communication and SignalingKanner's SyndromeLineage TracingLogicMacrocephalyMaintenanceMapsMediatingMegacephalyMegalocephalyMicrocephalyModelingModern ManMolecularMutationNerve CellsNerve UnitNeural CellNeurocyteNeurodevelopmental DisorderNeurological Development DisorderNeuronsPopulationPrincipal InvestigatorProductionProliferatingRadialRadiusSchizophreniaSchizophrenic DisordersSeizure DisorderServicesSignal TransductionSignal Transduction SystemsSignalingTherapeuticTimeTissue GrowthWorkagyriaautism spectral disorderautism spectrum disorderautistic spectrum disorderbalancebalance functionbiological signal transductionbrain deformitybrain malformationcell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular lineage mappingcellular lineage trackingcongenital brain anomalycongenital brain deformitycortical progenitorscortical stem celldementia praecoxdevelopmentalepilepsiaepileptogenicgene manipulationgenetic manipulationgenetically manipulategenetically perturbgenome mutationimaginginnovateinnovationinnovativeinsightlissencephalylissencephaly pachygyriamicrencephalymicroencephalymouse geneticsneurodevelopmental diseaseneuronalneuronal circuitneuronal circuitryneuronal growthontogenyoptogeneticsprogenitorschizophrenicsingle cell genomics
Description preview
Principal Investigator (Last, First, Middle): Anton, Eva S.
PROJECT SUMMARY
Radial progenitors serve as an instructive matrix to coordinate the generation and placement of
appropriate number and types of neurons in the developing cerebral cortex. Radial progenitors
divide asymmetrically to generate neurogenic intermediate progenitors (IPs) and the…
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