grant
Defining correlates of protection from dengue illness in a long-term cohort study of multigenerational house-holds in Thailand
Organization UPSTATE MEDICAL UNIVERSITYLocation SYRACUSE, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20250-11 years old7S Gamma GlobulinAcuteAddressAntibodiesAntibody titer measurementAntigensArboviralArbovirusesAreaArthropod-Borne VirusesBenchmarkingBest Practice AnalysisBreakbone Fever VirusBreast FeedingBreast fedBreastfedBreastfeedingCessation of lifeChildChild YouthChildren (0-21)ClinicalCohort StudiesCommunicable DiseasesConcurrent StudiesCustomDENVDENV infectionDENV vaccineDeathDengueDengue InfectionDengue VaccineDengue VirusDengue fever virusDengue virus infectionDengue virus vaccineDevelopmentDiagnosticDiseaseDisorderEnrollmentEnvironmentExposure toFamilyFlavivirusFundingFutureGenerationsGoalsGroup B ArbovirusHealthHistoryHouseholdHumanHumoral ImmunitiesIgGImmuneImmune mediated therapyImmunesImmunityImmunochemical ImmunologicImmunoglobulin GImmunologicImmunologicalImmunologicallyImmunologically Directed TherapyImmunologicsImmunology procedureImmunotherapyIncidenceIndividualInfantInfectionInfectious DiseasesInfectious DisorderJapanese B Encephalitis VirusJapanese encephalitis virusKineticsKnowledgeLocalesLong-term Follow-upLong-term cohort studyLongitudinal cohort studyMalariaMapsMaternal ImmunityMaternally-Acquired ImmunityMath ModelsMediatingMissionModelingModern ManMothersNIAIDNational Institute of Allergy and Infectious DiseaseNational Institutes of HealthOrthoflavivirusOutcomePaludismPathogenesisPhenotypePlasmodium InfectionsPopulation SurveillancePregnant WomenPublic Health SurveillanceRecording of previous eventsResearchResearch SpecimenRiskSafetySalivaSamplingSerotypingShapesSpecimenTechniquesTestingThailandTimeTriageUnited States National Institutes of HealthVAC-TXVaccinatedVaccinationVaccine TherapyVaccinesViral DiseasesVirus DiseasesZIKVZIKV infectedZIKV infectionZIKV positiveZika VirusZika virus infectionantibody titeringantibody-based immunitybenchmarkcohortcross reactivitycustomsdengue viral infectiondevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentalefficacy trialenrollexpectant motherexpectant womenexpectationexpecting motherexpecting womenhistoriesimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunogenicityimmunologic assayimmunologic assay/testindividuals who are pregnantinfected with ZIKVinfected with zikainnovateinnovationinnovativekidslong-term followupmathematic modelmathematical modelmathematical modelingpeople who are pregnantplacental transferpregnant femalespregnant motherspregnant peoplepregnant populationsprenatalpreventpreventingprimary outcomeprotective effectsecondary infectionseroconversionsevere denguetherapeutic vaccinationthose who are pregnanttoolunbornvaccine against DENVvaccine against denguevaccine candidate against denguevaccine developmentviral infectionviral transmissionvirus infectionvirus transmissionvirus-induced diseasewardwomen who are pregnantyoungsterzika infectedzika infectionzika viral infectionzikav
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PROJECT SUMMARY
Dengue viruses (DENV) cause a significant and unchecked burden of human death and disease, with vaccine
development hindered by critical gaps in our understanding of how multi-serotypic protection against DENV is
generated, sustained, and subsequently identified in immunological assays. As the greatest risk for severe
dengue…
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