grant
Defining circuit mechanisms for the regulation of somatosensory feedback
Organization SALK INSTITUTE FOR BIOLOGICAL STUDIESLocation La Jolla, UNITED STATESPosted 1 Apr 2025Deadline 1 Apr 2029
NIHUS FederalResearch GrantFY2025AffectAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnatomic SitesAnatomic structuresAnatomyAnesthesiaAnesthesia proceduresAnimalsArchitectureAttenuatedBehaviorBehavioralBehavioral AssayBody partBrainBrain Nervous SystemBrain StemBrainstemCell Communication and SignalingCell NucleusCell SignalingComplexCuesCutaneousDiagnosisDisinhibitionDorsalDysfunctionElectrophysiologyElectrophysiology (science)EncephalonEngineering / ArchitectureEnvironmentFaceFeedbackFoundationsFunctional disorderHandHydrogen OxideIntracellular Communication and SignalingLogicMiceMice MammalsModalityMolecularMolecular GeneticsMovementMurineMusNeocortexNerve CellsNerve UnitNervous SystemNeural CellNeurocyteNeurologic Body SystemNeurologic Organ SystemNeuronsNeurophysiology / ElectrophysiologyNucleusOpticsPathologicPathway interactionsPhasePhysiopathologyPopulationPreparationProprioceptionRegulationReportingSensorySensory ProcessSignal TransductionSignal Transduction SystemsSignalingSkinSliceSomatic Sensation DisordersSomatosensory DisordersStimulusStructureStructure of nucleus cuneatusSynapsesSynapticTactileTestingThalamic structureThalamusTherapeutic InterventionTouchTouch sensationTransmissionViralWaterWorkamygdaloid nuclear complexattenuateattenuatesbehavior influencebehavioral influencebiological signal transductionbody movementcuneate nucleusdorsal columnelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsextracellularfacesfacialgenetic approachgenetic strategyhandshomotypical corteximprovedinhibitory neuroninsightintervention therapyisocortexneopalliumneural circuitneural circuitryneurocircuitryneuronalopticaloptogeneticspathophysiologypathwayperceptual stimulusphysicochemical phenomena related to the sensesposterior columnpreparationsresponsesensory feedbacksensory stimulussomatosensorysynapsesynaptic circuitsynaptic circuitrytactile sensationtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthalamictransmission processvigilance
Description preview
PROJECT SUMMARY
Sensory feedback is critical for reporting the state of the body and how it interacts with the world. Yet the
incessant transmission of all sensory stimuli that impinge upon the body would be debilitating. Rather, sensory
signals must be regulated dynamically to attenuate the disruptive and facilitate the salient. The dorsal column…
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