grant

Defining Centriolar Plaque Architecture and Function Across Eukaryotic Diversity Using Expansion Microscopy and Proteomics

Organization INDIANA UNIVERSITY INDIANAPOLISLocation INDIANAPOLIS, UNITED STATESPosted 1 Mar 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026ArchitectureCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell LineCell Nucleus DivisionCell PolarityCell divisionCellLineClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyDinoflagellatesDinoflagellidaDinophyceaeEngineering / ArchitectureEukaryotaEukaryoteEukaryotic CellKaryokinesisM PhaseMTOCMapsMicroscopyMicrotubule-Organizing CenterMitosisMitosis StageMolecularOrganellesProcessProteinsProteomicsPyrrophytaResearchResearch ProposalsRoleStrains Cell LinesSystemTaxonWorkcellular polaritycomparativecultured cell linehigh definitionhigh resolution imaginghigh-resolutioninsightknock-downknockdownnuclear divisionsegregationsocial role
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Description preview

This research proposal aims to decode the structural and molecular architecture of centriolar plaques (CPs), a
non-centrosomal microtubule organizing center, in the context of atypical eukaryotic cell division. Using

expansion microscopy (U-ExM), we will map CP composition and dynamics with high resolution investigating

their roles in MTOC…

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Defining Centriolar Plaque Architecture and Function Across Eukaryotic Diversity Using Expansion Microscopy and Proteomi | Dev Procure