grant
Defining and targeting CIC::DUX4-dependent survival in fusion-positive sarcomas
NIHUS FederalResearch GrantFY202521+ years oldATAC sequencingATAC-seqATACseqAdultAdult HumanAggressive Clinical CourseAssayAssay for Transposase-Accessible Chromatin using sequencingBasal Transcription FactorBasal transcription factor genesBioassayBiological AssayBiologyBone TissueCRISPRCRISPR/Cas systemCancersCell BodyCell Communication and SignalingCell LineCell SignalingCell SurvivalCell ViabilityCellLineCellsChIP SequencingChIP-seqChIPseqCharacteristicsChemoresistanceChildhoodChildhood CancersChimera ProteinChimeric ProteinsClinicalClinical TrialsClustered Regularly Interspaced Short Palindromic RepeatsCollectionConsensusDNA mutationDataDependenceDiagnosisDiseaseDisease ProgressionDisorderDysfunctionEWSR1EWSR1 geneEWSR2Ewing Sarcoma Breakpoint Region 1Ewing Sarcoma Breakpoint Region 2Ewing's Family of TumoursEwing's Sarcoma/Peripheral Primitive Neuroectodermal TumorEwing's TumorEwings sarcomaExpression SignatureFLI1FLI1 geneFamilyFli-1 proto-oncogene, ETS transcription factorFriend leukemia virus integration 1Functional disorderFusion Oncogene ProteinsFusion ProteinFutureGene ExpressionGene Expression ProfileGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic ChangeGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGenetic TranscriptionGenetic defectGenetic mutationGenomeGenomic SegmentGenomicsHistone AcetylaseHumanHuman Cell LineImmunocompetentInferiorIntracellular Communication and SignalingInvestmentsLiteratureMalignant Childhood NeoplasmMalignant Childhood TumorMalignant NeoplasmsMalignant Pediatric NeoplasmMalignant Pediatric TumorMalignant Soft Tissue NeoplasmMalignant TumorMalignant childhood cancerMediatingMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMethodsMiceMice MammalsModelingModern ManMolecularMolecular GeneticsMolecular TargetMurineMusMutationNeoplasm MetastasisOncogene ProductsOncogene ProteinsOncogenesisOncogenicOncoproteinsOutcomePathogenesisPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPhasePhenotypePhysiopathologyPopulationPrognosisProliferatingProtein ArrayProteinsProteomicsPublishingRNA ExpressionRNA SeqRNA sequencingRNAseqRecombinant DNA TechnologyRecurrenceRecurrentResearchRoleRunningSIC-1SarcomaSecondary NeoplasmSecondary TumorShapesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStrains Cell LinesSystemTechnologyTherapeutic InterventionTimeTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTumor CellValidationWorkZNF217ZNF217 geneZinc Finger Protein 217adult youthadulthoodassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbiological signal transductioncancer in a childcancer in childrencancer metastasischemoresistantchemotherapy resistancechemotherapy resistantchild with cancerchildhood malignancychromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcultured cell linediagnostic assaydifferential expressiondifferentially expresseddisease modeldisorder modelexperimentexperimental researchexperimental studyexperimentsfunctional genomicsfusion genefusion oncoproteingene conservationgene expression patterngene expression signaturegenetically engineeredgenome mutationgenome segmentgenomic regionhistone acetyltransferasehuman modelimmune competentimprovedin vivointerestintervention therapymalignancymalignant soft tissue tumormembermodel of humanmouse modelmurine modelneoplasm/cancerneoplastic cellnew diagnosticsnext generation diagnosticsnovel diagnosticspathophysiologypathwaypatient oriented outcomespediatricpediatric cancerpediatric malignancyprogramsrecruitresponseshRNAshort hairpin RNAsmall hairpin RNAsocial rolesoft tissuetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttooltranscription factortranscriptional differencestranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingtranscriptomicstumortumor cell metastasistumorigenesisvalidationsyoung adultyoung adult ageyoung adulthood
Description preview
Abstract
The same intensity applied to identifying molecular targets, investing in research, and running clinical
trials that is occurring now for adult cancers has not extended to the pediatric population, despite evidence that
doing so in pediatric cancers will improve patient outcomes. An amenable context for targeted therapies is fusion-…
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