grant
Decoding the mechanisms of cell-cell fusion - Renewal - 1
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 4 May 2020Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2026ActinsAffectAlbers-Schoenberg DiseaseAlbers-Schonberg diseaseBinding SitesBiochemistryBiological ChemistryBiological FunctionBiological ProcessBiologyBiophysicsBone remodelingBrachydanio rerioCannot achieve a pregnancyCell BodyCell LineCell fusionCell membraneCellLineCellsCellular MatrixCellular biologyCholesterolCombining SiteConceptionsCytoplasmic MembraneCytoskeletal SystemCytoskeletonDNA Molecular BiologyDanio rerioDefectDephosphinDevelopmentDifficulty conceivingDiseaseDisorderDrosophilaDrosophila genusDucheneDuchenneDuchenne muscular dystrophyDuchenne-Griesinger syndromeDynaminEPH GestosisElectron MicroscopyEllis-van Creveld (EvC) syndromeEmbryonic Muscle CellsF-ActinFailureFertilizationFiberFilamentous ActinGTP PhosphohydrolasesGTPasesGenesGeneticGrantGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesImageImmune responseInfertilityInvadedLaboratoriesLearningLipidsMarble Bone DiseaseMechanicsMediatingMembraneMembrane BiologyMiceMice MammalsModelingMolecular BiologyMurineMusMuscle DevelopmentMuscle satellite cellMuscular DevelopmentMuscular DystrophiesMyoblastsMyodystrophicaMyodystrophyOrganOrganismOsteopetrosisOsteosclerosis FragilisPatternPhenotypePhysiologyPlacental DevelopmentPlacentationPlasma MembranePre-EclampsiaPrecursor Muscle CellsPreeclampsiaPregnancy ToxemiasProcessProteinuria-Edema-Hypertension GestosisPseudohypertrophic Muscular DystrophyReactive SiteResearchSignal PathwaySkeletal MuscleStrains Cell LinesSynapsesSynapticTherapeuticTherapeutic Steroid HormoneTranscriptional ControlTranscriptional RegulationVesicleVirusVoluntary MuscleX-linked dilated cardiomyopathyX-linked muscular dystrophyX-linked recessive muscular dystrophyZebra DanioZebra FishZebrafishbenign X-linked recessive muscular dystrophybiophysical foundationbiophysical principlesbiophysical sciencescell biologychildhood pseudohypertrophic muscular dystrophyclassic X-linked recessive muscular dystrophycongenital myopathycultured cell linedevelopmentaldriving forcefertility cessationfertility lossfertilizationsfruit flyguanosinetriphosphatasehormonal signalshormone signalshost responsehuman diseasehypoimmunityimagingimmune deficiencyimmune system responseimmunodeficiencyimmunoresponsein vivoinfertileinsightintracellular skeletonliving systemmarble bonemechanicmechanicalmembrane structuremild X-linked recessive muscular dystrophymuscle dystrophymuscle regenerationnovelplasmalemmapre-eclampticpregnancy toxemia/hypertensionprogressive muscular dystrophy of childhoodpseudohypertrophic adult muscular dystrophypseudohypertrophic muscular paralysisreconstitutereconstitutionresponsesatellite cellsteroid hormonesuperresolution microscopysynapse
Description preview
PROJECT SUMMARY/ABSTRACT
Cell-cell fusion is critical to the conception, development, and physiology of multicellular organisms, and is
involved in a variety of biological processes, such as fertilization, placenta development, bone remodeling,
immune response, and skeletal muscle development and regeneration. Failure in cell fusion leads to…
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