grant
Decoding the Cell-specific Impact of Epigenomic and Alternative Splicing Regulation during T1D Progression
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 1 Aug 2025Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025(TNF)-αATACATAC sequencingATAC-seqATACseqAffectAllelesAllelomorphsAlternate SplicingAlternative RNA SplicingAlternative SplicingAssayAssay for Transposase-Accessible Chromatin using sequencingB9 endocrine pancreasBeta CellBeta Proprotein Interleukin 1BioassayBiologicalBiological AssayBiological FunctionBiological ProcessBiologyBrittle Diabetes MellitusCRISPRCRISPR/Cas systemCachectinCell BodyCell CommunicationCell Communication and SignalingCell DeathCell InteractionCell LineCell NucleusCell SignalingCell-to-Cell InteractionCellLineCellsChromatinChromosome MappingClustered Regularly Interspaced Short Palindromic RepeatsDevelopmentDiabetes MellitusDiseaseDisease ProgressionDisorderEffector CellEndocrineEndocrine PancreasEndothelial CellsEnvironmentExposure toGWA studyGWASGene ExpressionGene LocalizationGene MappingGene Mapping GeneticsGene variantGenesGeneticGenomicsGenotypeGoalsGripsHumanHyperglycemiaIDDMIFN-GammaIFN-gIFN-γIFNGIFNγIL-1 betaIL-1 βIL-1-bIL-1βIL1-BetaIL1-βIL1B ProteinIL1F2IL1βImmuneImmune InterferonImmune signalingImmunesIndividualInflammatoryInnate Immune ResponseInsulin CellInsulin Secreting CellInsulin-Dependent Diabetes MellitusInterferon GammaInterferon Type IIInterleukin 1betaInterleukin-1 betaInterleukin-1βIntracellular Communication and SignalingIslands of LangerhansIslet CellIslets of LangerhansIsoformsJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKnowledgeLPTNLaboratoriesLeadLengthLinkage MappingMacrophageMacrophage-Derived TNFMapsModelingModern ManMolecularMolecular GeneticsMonocyte-Derived TNFMultiomic DataMφNesidioblastsNon-Polyadenylated RNANucleusOrganoidsPancreatic IsletsPancreatic beta CellPancreatic β-CellPars endocrina pancreatisPatientsPb elementPersonalized medical approachPhenotypePhysiologicPhysiologicalPlayPrecision therapeuticsPreinterleukin 1 BetaProgenitor CellsProtein IsoformsQTLQuantitative Trait LociRNARNA Gene ProductsRNA SeqRNA SplicingRNA sequencingRNAseqRegulationRegulator GenesRegulatory ElementReporterResearchResolutionRibonucleic AcidRoleSCM-1SCM-1aSCM1SCYC1SamplingSignal TransductionSignal Transduction SystemsSignalingSingle Base PolymorphismSingle Nucleotide PolymorphismSingle-Nucleus SequencingSplicingStrains Cell LinesStructure of beta Cell of isletSudden-Onset Diabetes MellitusT-CellsT-LymphocyteT1 DMT1 diabetesT1DT1DMTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTotal Human and Non-Human Gene MappingTranscriptTranscriptional Regulatory ElementsTumor Necrosis FactorTumor Necrosis Factor-alphaType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusValidationVascularizationVirusXCL1XCL1 geneadaptive immune responseallelic variantassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbiologicbiological signal transductioncausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcell typecultured cell linecytokinedata sharingdevelopmentaldiabetesdiscover geneseffective therapyeffective treatmentenvironmental changeepigenomicsexperimentexperimental researchexperimental studyexperimentsfunctional genomicsgene discoverygene functiongenetic mappinggenetic trans acting elementgenetic variantgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic variantglobal gene expressionglobal transcription profilegraspheavy metal Pbheavy metal leadhuman derived pluripotent stem cellhuman pluripotent stem cellhyperglycemicimprovedindividualized approachinsightinsulin dependent diabetesinsulin dependent type 1insulitisisletislet progenitorislet stem cellsjuvenile diabetesjuvenile diabetes mellitusketosis prone diabetesknock-downknockdownlFN-Gammalong read seqlong-read sequencinglong-read transcript sequencingmultiomicsmultiple omic datamultiple omicsnecrocytosisnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoverexpressoverexpressionpancreas beta cellpancreas progenitor cellpancreas stem cellspancreas β cellpancreatic b-cellpancreatic progenitorpancreatic progenitor cellpanomicspersonalized approachprecision approachprecision medicineprecision therapiesprecision treatmentprecision-based medicineprogenitor cell modelprogenitor modelprogression biomarkerprogression markerregulatory generesolutionsresponsesNuc-SeqscATAC sequencingscATAC-seqsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell sequencing assay for transposase accessible chromatinsingle nucleotide variantsingle nucleus RNA-sequencingsingle nucleus seqsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolestem and progenitor cell modelstem cell based modelstem cell derived modelstem cell modelstem cell organoidsstem cell-derived organoidsstem cellstailored approachtherapeutic targetthymus derived lymphocytetrans acting elementtranscriptometranscriptome sequencingtranscriptomic sequencingtype I diabetestype one diabetesvalidationswhole genome association analysiswhole genome association studyβ-cellβ-cellsβCell
Description preview
Abstract.
Type 1 diabetes (T1D) is characterized by the destruction of pancreatic β cells, which respond to signals from
immune cells, leading to hyperglycemia. This study aims to grasp the mechanisms influencing T1D by
investigating both intrinsic β cell factors and environmental immune cell interactions. Our interdisciplinary team
combines…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click