grant
Decoding multidrug-resistant pathogen dynamics for clinically-relevant wastewater surveillance
Organization CHILDREN'S HOSP OF PHILADELPHIALocation PHILADELPHIA, UNITED STATESPosted 23 Jul 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoVAddressAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsAntimicrobial ResistanceBacterial InfectionsBechuanalandBioinformaticsBiological TestingBotswanaCOVID crisisCOVID epidemicCOVID pandemicCOVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 virusCOVID-19 yearsCOVID19 virusCarbapenem resistance in EnterobacteralesChildhoodChildren's HospitalClinicalCoV-2CoV2CommunitiesComplementComplement ProteinsDataData AnalysesData AnalysisDetectionDevelopmentDisease OutbreaksElementsEnabling FactorsEnvironmentEnvironmental FactorEnvironmental Risk FactorEpidemiologic MonitoringEpidemiologic surveillanceEpidemiological MonitoringEpidemiological surveillanceEpidemiologyEpidemiology SurveillanceFunctional MetagenomicsGenetic MaterialsGenomicsGenotypeGoalsHealth Care CostsHealth Care SystemsHealth CostsHorizontal Gene TransferHospitalsInfectionInfection ControlInfection preventionInfrastructureLMICLateral Gene TransferLinkLow-resource areaLow-resource communityLow-resource environmentLow-resource regionLow-resource settingMDR organismMDR pathogenMetagenomicsMethodologyMethodsMiscellaneous AntibioticMobile Genetic ElementsMolecularMonitorMorbidityMorbidity - disease rateMulti-Drug ResistanceMultidrug ResistanceMultiple Anti-bacterial Drug ResistanceMultiple Anti-bacterial Drug ResistantMultiple Bacterial Drug ResistanceMultiple Drug ResistanceMultiple Drug ResistantOutbreaksOutcomePatientsPediatric HospitalsPlasmidsPlumbingPopulationPostdocPostdoctoral FellowPrevalencePrevent infectionProtocolProtocols documentationPublic HealthResearchResearch AssociateResearch ResourcesResistanceResistance to Multi-drugResistance to MultidrugResistance to Multiple Anti-bacterial DrugResistance to Multiple DrugResistance to antibioticsResistant to Multiple Anti-bacterial DrugResistant to Multiple DrugResistant to antibioticsResistant to multi-drugResistant to multidrugResource-constrained areaResource-constrained communityResource-constrained environmentResource-constrained regionResource-constrained settingResource-limited areaResource-limited communityResource-limited environmentResource-limited regionResource-limited settingResource-poor areaResource-poor communityResource-poor environmentResource-poor regionResource-poor settingResourcesSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 pandemicSARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SamplingSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 pandemicSevere acute respiratory syndrome related corona virus 2SiteStandardizationSystemTechniquesTestingTherapeuticThinkingTranslatingTreatment FailureUnited StatesWorkWuhan coronavirusanti-microbial resistantantibiotic drug resistanceantibiotic resistantbacteria infectionbacterial diseasebeta lactam antibioticbeta-Lactamsbio-informatics pipelinebioinformatics pipelinecarbapenem resistant Enterobacteralescarbapenem resistant Enterobacterialesclinical applicabilityclinical applicationclinical careclinical relevanceclinical sequencingclinically relevantcombatcomplementationcoronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease 2019 viruscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease pandemiccoronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccoronavirus disease-19 viruscostcost effectivedata interpretationdesigndesigningdevelopmentalenvironmental riskepidemiologicepidemiologicalexperiencehCoV19health care settingshospital careimprovedinnovateinnovationinnovativelow and middle-income countriesmicrobial consortiamicrobial floramicrobiomemicrobiotamicrofloramicroorganismmortalitymulti-drug resistantmulti-drug resistant bacteriamulti-drug resistant organismmulti-drug resistant pathogenmultidrug resistantmultidrug resistant bacteriamultidrug resistant organismmultidrug resistant pathogenmultiple drug resistant organismmultiple drug resistant pathogenmultispecies consortianCoV2novelpathogenpediatricpost-docpost-doctoralpost-doctoral traineeresearch associatesresistance generesistance locusresistance mechanismresistance to anti-microbialresistantresistant generesistant mechanismresistant to antimicrobialresponsesevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsurveillance strategytherapy failurethoughtstoolwaste water based surveillancewaste water based testingwaste water samplingwaste water surveillancewaste water testingwastewater based surveillancewastewater based testingwastewater samplingwastewater surveillancewastewater testingβ lactam antibioticβ-Lactams
Description preview
Multidrug-resistant bacteria (MDRB) contribute increasingly to morbidity, mortality, and healthcare
costs. Extended-spectrum beta-lactam- and carbapenem-resistant Enterobacterales (ESBL-E
and CRE) are MDRB of particular concern due to their demonstrated ability to evolve into highly
transmissible clones and acquire and spread antibiotic resistance…
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