grant
Decoding ensemble dynamics from cortico-amygdalar circuits during social choice
NIHUS FederalResearch GrantFY20253,4 methylenedioxymethamphetamineAbsence of pain sensationAbsence of sensibility to painAcuteAlgorithmsAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnimalsAnteriorBayesian ModelingBayesian adaptive designsBayesian adaptive modelsBayesian belief networkBayesian belief updating modelBayesian frameworkBayesian hierarchical modelBayesian network modelBayesian nonparametric modelsBayesian spatial data modelBayesian spatial image modelsBayesian spatial modelsBayesian statistical modelsBayesian tracking algorithmsBehaviorBehavioralBehavioral ModelBehavioral ParadigmCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesClinicalComputer ModelsComputerized ModelsComputing MethodologiesCrystal MethCrystal methamphetamineDataDecision MakingDeoxyephedrineDesoxyephedrineDimensionsDrugsEmpathyEnvironmentFDA approvedFeelingFeels no painGoalsHealthHumanImpairmentInterventionInvestigatorsJointsK-AwardsK-Series Research Career ProgramsMDMAMachine LearningMeasuresMediatorMedicationMentorsMethamphetamineMethodsMethylamphetamineMethylenedioxymethamphetamineMiceMice MammalsModern ManMurineMusN,alpha-dimethyl-1,3-benzodioxole-5-ethanamineN-Methyl-3,4-methylenedioxyamphetamineN-MethylamphetamineNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocyteNeuronal TransmissionNeuronsNeurosciencesNo sensitivity to painNon-linear DynamicNon-linear DynamicsNonlinear DynamicNonlinear DynamicsNucleus AccumbensPTSDPainPainfulPartner in relationshipPharmaceutical PreparationsPost-Traumatic NeurosesPost-Traumatic Stress DisordersPosttraumatic NeurosesPrimatesPrimates MammalsProbabilistic ModelsProbability ModelsResearchResearch Career ProgramResearch PersonnelResearchersRewardsRodentRodentiaRodents MammalsRoleSocial BehaviorSocial ChangeSocial EnvironmentSocial InteractionSocial ProcessesSocial modificationSocial transformationSpace ModelsStatistical ModelsStimulusStressStructureSubgroupSystemTestingTrainingamygdaloid nuclear complexanalgesiaaxon signalingaxon-glial signalingaxonal signalingbehavioral pharmacologycareercingulate cortexclinical significanceclinically significantcomputational methodologycomputational methodscomputational modelingcomputational modelscomputer based methodcomputer based modelscomputer methodscomputerized modelingcomputing methoddeep learningdeep learning based modeldeep learning methoddeep learning modeldeep learning strategydrug/agentecstasyexperienceexperimentexperimental researchexperimental studyexperimentsfeelingsglia signalingglial signalingindividual heterogeneityindividual variabilityindividual variationinnovateinnovationinnovativemachine based learningmatemethnerve signalingneuralneural circuitneural circuitryneural mechanismneural modelneural signalingneurocircuitryneuromechanismneuronalneuronal circuitneuronal circuitryneuronal signalingneuropsychiatricneuropsychiatryneurotransmissionnoveloptogeneticspharmacobehavioralpharmacologicpost-trauma stress disorderposttrauma stress disorderpreferenceresponseskillssocialsocial anxietysocial biassocial climatesocial cognitionsocial contextsocial learningsocial relationshipssocial rolesocially anxioussociobehaviorsociobehavioralsocioenvironmentsocioenvironmentalstatistical linear mixed modelsstatistical linear modelssynaptic circuitsynaptic circuitrytooltraumatic neurosisunsupervised clusteringvector
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Project Summary
Social relationships are a key component of human health and survival and impairments in social
behavior have a major impact in many psychiatric conditions. Yet despite the importance of social
context to health, there remains no FDA-approved medications that target social cognition and
behavior. Social context is defined by the…
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