grant
Decoding and Reprogramming Redox Signal Transduction Pathways
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Aug 2020Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026AD dementiaActive OxygenAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAutoregulationBacteriaBiochemistryBiologicalBiological ChemistryCancersCarbon MonoxideCardiovascular DiseasesCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessDiseaseDisorderEndogenous Nitrate VasodilatorEndothelium-Derived Nitric OxideEnvironmentEnzymatic BiochemistryEnzyme GeneEnzymesEnzymologyEquilibriumGoalsGrantHealthHeme IronHomeostasisHumanInorganic ChemistryIntracellular Communication and SignalingLifeLinkMaintenanceMalignant NeoplasmsMalignant TumorMetalloproteinsModalityModern ManMolecularMononitrogen MonoxideNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersNitric OxideNitrogen MonoxideNitrogen ProtoxideOrganism-Level ProcessOrganismal ProcessOxidation-ReductionOxygen RadicalsPhenotypePhysiologicPhysiologic ProcessesPhysiologicalPhysiological HomeostasisPhysiological ProcessesPlantsPrimary Senile Degenerative DementiaPro-OxidantsProcessProtein EngineeringReactionReactive Oxygen SpeciesReagentRedoxResearchSensitivity and SpecificitySideSignal PathwaySignal TransductionSignal Transduction PathwaySignal Transduction SystemsSignalingSpecificitySpectroscopySpectrum AnalysesSpectrum AnalysisStressStructureSubcellular ProcessTechniquesbalancebalance functionbiologicbiological signal transductioncardiovascular disordercell behaviorcellular behaviorcopingdesigndesigningendothelial cell derived relaxing factorgenetic protein engineeringmalignancyneoplasm/cancerneurological diseasenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoxidation reduction reactionprimary degenerative dementiaprogramsprotein designresponsesenile dementia of the Alzheimer typesensorstimulus sensitivitystructural biology
Description preview
Project Summary
Cells have evolved intricate enzymatic machineries that help them exist and survive redox stresses in their
microenvironment. Enzymatic redox sensing, signaling, and response mechanisms are critical for a diverse set
of physiological processes in all forms of life ranging from bacteria and plants to humans. Unlike other cellular…
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