grant
Deciphering The Role of RNA Modifications In Maternal Mrna Clearance
Organization OLD DOMINION UNIVERSITYLocation NORFOLK, UNITED STATESPosted 15 Aug 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY20263' exonucleaseAddressAmino Acid SubstitutionAreaAssayBioassayBiologicalBiological AssayCatalogsCell BodyCellsCodeCoding SystemComprehensionCoupledDiseaseDisorderEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentFutureGene Action RegulationGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenetic TranscriptionGenomeHealthHumanIndividualInosineMaternal Messenger RNAMaternal mRNAMessenger RNAModelingModern ManModificationMolecularMolecular AnalysisNon-Polyadenylated RNAOocytesOrganOrganismOvocytesPlatannaPoly(A) TailProcessProteomicsRNARNA ExpressionRNA Gene ProductsRNA ProcessingRNA SeqRNA StabilityRNA metabolismRNA sequencingRNAseqResearchRibonucleic AcidRibosomesRoleTestingTranscriptTranscriptionTranslation ProcessTranslationsWorkXenopus laevisbiologicbiological systemscatalogimaging in vivoin vivo imaginginnovateinnovationinnovativeinsightliving systemmRNAmRNA DegradationmRNA StabilitymRNA Transcript Degradationnovelphosphodiesterase IIposttranscriptionalrecruitsocial rolespleen exonucleasespleen phosphodiesterasetranscriptome sequencingtranscriptomic sequencingtranslationtranslational impact
Description preview
Abstract
Maternal RNA clearance is an essential process that occurs in the absence of transcription in all sexually
reproducing species examined. Stored maternal transcripts sustain early embryonic development prior to
activation of the embryonic genome. Perturbations of maternal mRNA degradation can either halt or irreparably
alter the…
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