grant
Deciphering the role of regulatory T cell derived Mmp12 in lung injury resolution
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025ARDSAccelerationAcute Lung InjuryAcute Pulmonary InjuryAcute Respiratory DistressAcute Respiratory Distress SyndromeAdult ARDSAdult RDSAdult Respiratory Distress SyndromeAffectAgeAlveolusAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAreaAssayBioassayBioinformaticsBiological AssayBiological MarkersBlood NeutrophilBlood Polymorphonuclear NeutrophilBronchial AlveolusBronchoalveolar Lavage FluidCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCOVID infected patientCOVID patientCOVID positive patientCOVID-19 infected patientCOVID-19 patientCOVID-19 positive patientCOVID19 patientCOVID19 positive patientCell BodyCell Cycle KineticsCell FunctionCell IsolationCell KineticsCell PhysiologyCell ProcessCell SegregationCell SeparationCell Separation TechnologyCell TherapyCellsCellular FunctionCellular PhysiologyCellular ProcessCellular biologyChemoattractantsChemotactic FactorsChemotaxinsClinical TrialsClottingCoagulationCoagulation ProcessCollaborationsCommunicationComplement ActivationDa Nang LungDefectDevelopment and ResearchEducational workshopEthicsExperimental ModelsFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGasesGene ModifiedGrippeHeterogeneityHistologyImmuneImmunesInflammationInflammatoryInfluenzaInfluenza AInfluenza A virusInfluenza Viruses Type AInfluenzavirus AInjuryKineticsLaboratoriesLife StyleLifestyleLungLung DiseasesLung InflammationLung Respiratory SystemLung damageMME geneMMP12ManuscriptsMarrow NeutrophilMeasuresMechanical ventilationMediatingMediatorMetallopeptidasesMetalloproteasesMetalloproteinasesMethodsMiceMice MammalsMurineMusNeutrophil InfiltrationNeutrophil RecruitmentNeutrophilic GranulocyteNeutrophilic InfiltrateNeutrophilic LeukocyteOrthomyxovirus Type APathologyPatientsPersonsPneumonitisPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationPreparationPropertyProteinsProteomicsPulmonary DiseasesPulmonary DisorderPulmonary EdemaPulmonary InflammationR & DR&DRegulatory T-LymphocyteResearchResidualResidual stateResolutionRoleSARS-CoV-2 infected patientSARS-CoV-2 patientSARS-CoV-2 positive patientSeriesSeveritiesShock LungStiff lungSubcellular ProcessSurvivorsT-Cell SubsetsT-Lymphocyte SubsetsT4 CellsT4 LymphocytesTestingTherapeuticTimeTranscriptTregType A InfluenzaUniversitiesUpregulationWild Type MouseWorkWorkshopagesbio-markersbiologic markerbiomarkercareer developmentcell based interventioncell biologycell mediated interventioncell mediated therapiescell sortingcell-based therapeuticcell-based therapycellular therapeuticcellular therapycompare to controlcomparison controlcomplement chemotactic factorcomplement pathway regulationcoronavirus disease 2019 infected patientcoronavirus disease 2019 patientcoronavirus disease 2019 positive patientcoronavirus disease infected patientcoronavirus disease patientcoronavirus disease positive patientcoronavirus disease-19 patientcoronavirus patientdifferential expressiondifferentially expresseddisease modeldisease of the lungdisorder modeldisorder of the lungethicalextracellularflow cytophotometrygene modificationgenetically modifiedhealingimprovedinjuriesinterestlung disorderlung edemalung functionlung injurylung repairlung tissue repairmRNA Expressionmacrophage metalloelastasemacrophage-specific metalloelastasematrix metalloproteinase 12mechanical respiratory assistmechanically ventilatedmortalitymouse modelmurine modelneutrophilnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathogenpatient infected with COVIDpatient infected with COVID-19patient infected with SARS-CoV-2patient infected with coronavirus diseasepatient infected with coronavirus disease 2019patient infected with severe acute respiratory syndrome coronavirus 2patient with COVIDpatient with COVID-19patient with COVID19patient with SARS-CoV-2patient with coronavirus diseasepatient with coronavirus disease 2019patient with severe acute respiratory distress syndrome coronavirus 2pleiotropic effectpleiotropismpleiotropypreparationsprotein expressionpulmonary damagepulmonary functionpulmonary injurypulmonary repairpulmonary tissue damagepulmonary tissue injuryregulatory T-cellsrepairrepairedresearch and developmentresolutionssevere acute respiratory syndrome coronavirus 2 infected patientsevere acute respiratory syndrome coronavirus 2 patientsevere acute respiratory syndrome coronavirus 2 positive patientskillssocial roletranscriptional differenceswet lungwildtype mouse
Description preview
ABSTRACT
Acute Respiratory Distress Syndrome (ARDS) is characterized by heightened lung inflammation and edema in
the alveoli and interstitium, affecting the lung's primary function of gas exchange. The treatment for ARDS has
improved over the years, but the mortality of 20-40% is still associated with ARDS, and the residual defects in
lung…
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