grant
Deciphering the Role of Mycobiome (Fungus) in Lung Carcinogenesis
Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 1 Dec 2024Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DA fumigatusA. fumigatusA549Active OxygenAddressAdvanced DevelopmentAlternariaAspergillus fumigatusAttentionB Cell Differentiation Factor IB cell growth factorB cell growth factor 2B-Cell Differentiation Factor-1B-Cell Growth Factor-1B-Cell Growth Factor-IB-Cell Growth Factor-IIB-Cell Proliferating FactorB-Cell Stimulating FactorB-Cell Stimulating Factor-1B-Cell Stimulation Factor-1B-Cell Stimulatory Factor-1BCDF-1BCGFBCGF-1BCGF-IIBCGF2BCSF 1BSF-1BSF1BacteriaBindingBinetrakinBlood NeutrophilBlood Polymorphonuclear NeutrophilBody TissuesCancer CauseCancer EtiologyCancer Gene MutationCancer GenesCancer InductionCancer-Promoting GeneCancersCell BodyCell Culture TechniquesCell LineCellLineCellsCellular StressCellular Stress ResponseClinicalCo-cultureCocultivationCocultureCoculture TechniquesCulture MediaCytosolDNADNA DamageDNA Damage RepairDNA InjuryDNA Mismatch Repair Protein MSH3DNA RepairDNA mutationDataData SetDeletion MutationDeoxyribonucleic AcidDepositDepositionDetectionDevelopmentDivergent Upstream ProteinEnvironmentEo-CSFEosinophil Differentiation FactorEpithelial CellsExhibitsExposure toFLJ11330FiltrationFiltration FractionationFungal SporesFungal ToxinsFungus DiseasesGene ExpressionGenetic ChangeGenetic Toxicity TestsGenetic defectGenetic mutationGenetics-MutagenesisGenomeGenome InstabilityGenomic InstabilityGenotoxicity TestsHumanIL-13IL-4IL-5IL13IL4 ProteinIgA enhancing factorImmuneImmune responseImmunesImmunityImpairmentIn VitroInduced DNA AlterationInduced MutationInduced Sequence AlterationInfectionInflammatory ResponseInsertion MutationInterleukin 5 PrecursorInterleukin-13Interleukin-4Interleukin-4 PrecursorInterleukin-5LifeLungLung Respiratory SystemLymphocyte Stimulatory Factor 1MCGF-2MacrophageMalignant CellMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMarrow Mast CellMarrow NeutrophilMast Cell Growth Factor-2MethodsMicrobeModelingModern ManMolecularMolecular InteractionMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMutagen ScreeningMutagenesisMutagenesis Molecular BiologyMutagenicity TestsMutationMycosesMycotoxinsMφNF-Kb-Activating Kinase GeneNeutrophilic GranulocyteNeutrophilic LeukocyteOncogenesOncogenesisOrganoidsOutcomeOxidative StressOxygen RadicalsPathway interactionsPatternPhenotypePolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPreventivePro-OxidantsPulmonary CancerPulmonary malignant NeoplasmQuantum MechanicsR-Series Research ProjectsR01 MechanismR01 ProgramReactive Oxygen SpeciesReproduction sporesResearchResearch GrantsResearch Project GrantsResearch ProjectsRespiratory EpitheliumRoleRouteSamplingSeriesShapesSingle Base PolymorphismSingle Nucleotide PolymorphismSingle cell seqSiteSporesStimulator of Interferon GenesStrains Cell LinesStructure of respiratory epitheliumStudy modelsSystemT cell replacing factorT-Cell Growth Factor 2T-Cell Replacing FactorT2KTBK1TBK1 geneTechnologyTestingTh-2 CellTh2 CellsTherapeuticTissue BasophilsTissuesTransforming GenesType 2 Helper CellUnscheduled DNA SynthesisVirusairway epitheliumcGAMP STINGcGAMP-STINGcGAMP/STINGcGAS/STINGcancer cellcancer cell genomecancer genomecancer initiationcancer progressioncancer specific gene mutationcarcinogenesiscarcinogenicitycell culturecell culturescell immortalizationcell stresscell typecompare to controlcomparison controlcultured cell linecyclic GMP-AMP synthase/STINGcytokinedesigndesigningdevelopmentaldirected differentiationexperimentexperimental researchexperimental studyexperimentsextracellularfungal infectionfungal microbiomefungal pathogenfungi pathogenfungusfungus infectiongain of function mutationgenome databasegenome mutationgrowth mediahealinghost responsehuman derived pluripotent stem cellhuman pluripotent stem cellimmune system responseimmunoresponsein vivoinnovateinnovationinnovativeloss of function mutationlung cancerlung carcinogenesismalignancymast cellmastocytemicrobiomemismatch repair protein 1molecular modelingmouse modelmurine modelmutagen testingmycobiomeneoplasm progressionneoplasm/cancerneoplastic progressionneutrophilnew diagnosticsnext generation diagnosticsnovelnovel diagnosticspathogenpathogenic funguspathwayrespiratoryrespiratory tract epitheliumresponseresponse to therapyresponse to treatmentsingle cell next generation sequencingsingle cell sequencingsingle nucleotide variantsocial rolesystems researchtherapeutic responsetherapy responsethree dimensionaltranscriptomicstreatment responsetreatment responsivenesstumortumor genometumor progressiontumorigenesistumorigenic
Description preview
The role of 'polymorphic microbes' in cancer development and progression has been extensively studied, but
research on the role of fungi (mycobiomes) is surprisingly limited. To address this gap, we have developed an
innovative 3D-organotypic lung (iLung) model derived from human pluripotent stem cells (hPSCs). This model
in combination with live…
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