grant
Deciphering the role of GFPT2 in radiation-induced cardiovascular disease
Organization UNIVERSITY OF TX MD ANDERSON CAN CTRLocation HOUSTON, UNITED STATESPosted 1 Aug 2025Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025ASCVDAccelerationAcetylationAddressAffectAmino SugarsAminotransferasesAtherosclerosisAtherosclerotic Cardiovascular DiseaseAtrial FibrillationAuricular FibrillationBlood VesselsBlood monocyteBody TissuesCancer PatientCardiac DiseasesCardiac DisordersCardiovascular DiseasesCell AgingCell BodyCell SenescenceCell Senescence InductionCellsCellular AgingCellular SenescenceChestDNADNA DamageDNA Damage RepairDNA InjuryDNA RepairDataDeacetylationDeoxyribonucleic AcidDevelopmentDihydronicotinamide Adenine DinucleotideDiphosphopyridine NucleotideEnzyme GeneEnzymesFeedbackGenomic DNAGlnGlutamate MetabolismGlutamate Metabolism PathwayGlutamatesGlutamineGlycosaminoglycansGoalsHeart DiseasesHumanIn VitroIncidenceInflammationIntermediary MetabolismInvestigationIonizing Electromagnetic RadiationIonizing radiationKO miceKnock-out MiceKnockout MiceL-GlutamateL-GlutamineLinkMacrophageMarrow monocyteMediatingMetabolicMetabolic ProcessesMetabolismModern ManMucopolysaccharidesMyeloid CellsMφNadideNicotinamide adenine dinucleotideNicotinamide-Adenine DinucleotideNull MousePARP InhibitorPARP PolymerasePARP proteinPARP-1 inhibitorPARPiPARSPatientsPlayPoly(ADP-ribose) Polymerase InhibitorPoly(ADP-ribose) PolymerasesPoly(ADP-ribose) polymerase 1 inhibitorPoly(ADPribose) PolymerasePreventative treatmentPreventive treatmentProcessProteinsQ LevoglutamideQ. LevoglutamideRadiationRadiation exposureRadiation therapyRadiation-Ionizing TotalRadiotherapeuticsRadiotherapyRegulationReplicative SenescenceRoleSilent Mating Type Information Regulator 2-like ProteinsSir2-like ProteinsSirtuinsSiteTestingTherapeuticThoraceThoracicThoraxTissuesTopoisomeraseTransaminasesUnscheduled DNA Synthesisaging processaminosugaratheromatosisatherosclerotic diseaseatherosclerotic vascular diseasecardiovascular disordercellular aging inductioncellular senescence inductiondevelopmentalfructose-6-phosphategDNAglutamatergicheart disorderhigh riskin vivoinhibitorinsightionizing outputirradiation induced senescencemitochondrial dysfunctionmonocytemutantnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpoly ADP polymerasepoly ADP ribose synthetasepreventpreventingprognosticradiation associated cardiovascular diseaseradiation caused senescenceradiation induced cardiovascular diseaseradiation induced cell senescenceradiation induced cellular senescenceradiation induced senescenceradiation mitigationradiation treatmentradiological mitigationradiomitigationreplicative agingsenescencesenescence and its associated secretory phenotypesenescence associated secretomesenescence associated secretory factorssenescence associated secretory pathwaysenescence associated secretory phenotypesenescence associated secretory programsenescence associated secretory proteinssenescence by radiationsenescence inductionsenescentsenescent associated secretomesenescent associated secretory phenotypesenescent cellsocial roletelomeretreatment with radiationvascular
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Project Summary/Abstract
Radiation-induced heart disease affects 15-30% of cancer patients who undergo radiation therapy (RT) to the chest
and encompasses a broad range of cardiovascular disease (CVD) with potentially profound prognostic implications.
Despite its impact, the exact causes of RICVD remain uncertain, and limited preventive treatments…
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