grant
Deciphering the Role of CTR1 Oligomeric States in Copper Homeostasis and Neuronal Differentiation
Organization UNIVERSITY OF HOUSTONLocation HOUSTON, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026AddressAllosteric RegulationAssayAutomobile DrivingAutoregulationBioassayBiochemicalBiological AssayBrain DiseasesBrain DisordersCell BodyCellsCollaborationsCopperCu elementDegenerative Neurologic DisordersDevelopmentDiagnosticDiseaseDisorderEncephalon DiseasesEndocytosisEnsureEventFutureGeneticGrowth AgentsGrowth FactorGrowth SubstancesHealthHomeostasisImpairmentIn SituIntracranial CNS DisordersIntracranial Central Nervous System DisordersLifeLinkMediatingMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMethodologyMicronutrientsMicroscopyNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurobiologyNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuronal DifferentiationNeuronal TransmissionNeuronsPathway interactionsPhysiologicPhysiologicalPhysiological HomeostasisProteinsProteins Growth FactorsProteomicsR-Series Research ProjectsR01 MechanismR01 ProgramRegulationResearchResearch GrantsResearch Project GrantsResearch ProjectsRoleSignal PathwayStem Cell ResearchStudy modelsSurface ProteinsSystemTherapeuticVisualizationaxon signalingaxon-glial signalingaxonal signalingcopper transporter 1degenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldrivingglia signalingglial signalinghESChESC modelhuman ES cellhuman ESChuman embryonic stem cellhuman embryonic stem cell based modelhuman embryonic stem cell derived modelhuman embryonic stem cell modelhuman progenitorhuman stem cellsinnovateinnovationinnovativeinsightmembrane structuremolecular imagingmolecule imagingmonomermultidisciplinarymutantnerve signalingneural signalingneurobiologicalneurodegenerative illnessneuronalneuronal signalingneurotransmissionnoveloverexpressoverexpressionpathwayprogenitor cell differentiationprogenitor cell modelprogenitor differentiationprogenitor modelsingle moleculesocial rolestem and progenitor cell modelstem and progenitor differentiationstem cell based modelstem cell derived modelstem cell differentiationstem cell modelstem cell studystoichiometrytraffickinguptake
Description preview
PROJECT SUMMARY
This proposal aims to elucidate how the dynamic oligomeric transitions of Copper Transporter 1 (CTR1) couple
copper (Cu) homeostasis with neuronal developmental pathways. Cu is an essential micronutrient for neuronal
function, and a deficiency of Cu in early life can have devastating impacts on development. We recently
discovered…
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