grant
Deciphering the Role of Bacterial Polyphosphates in Intestinal Immune Networks
Organization BOSTON UNIVERSITY MEDICAL CAMPUSLocation BOSTON, UNITED STATESPosted 1 Apr 2026Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY20265-Aminosalicylic AcidAdoptive TransferAffectAlimentary CanalArchitectureAsacolAutomobile DrivingBacteriaBlood PlasmaBlood SampleBlood SerumBlood specimenBody TissuesBody Weight decreasedBone MarrowBone Marrow Reticuloendothelial SystemCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCalorimetryCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell-to-Cell InteractionCellsCharacteristicsChimera ProteinChimeric ProteinsClinicClinicalColitisCollaborationsColonCrohn diseaseCrohn'sCrohn's diseaseCrohn's disorderDataDevelopmentDigestive TractDysfunctionE coliE. coliEdodekin AlfaEngineering / ArchitectureEnzyme GeneEnzymesEscherichia coliExposure toFamilyFunctional MetagenomicsFunctional disorderFusion ProteinGI TractGI microbiomeGastroenterologyGastrointestinal TractGastrointestinal tract structureGnotobioticGnotobioticsGranulomatous EnteritisGut MucosaHumanIL-12IL12ImmuneImmune EvasionImmunesImmunityImmunologic SubtypingImmunophenotypingIn VitroIndividualInflammationInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderInnate ImmunityInterferometryInterleukin-12Intermediary MetabolismIntestinalIntestinal DiseasesIntestinal DisorderIntestinesIntracellular Communication and SignalingJAK1JAK1 geneJAK1 proteinJAK1AJak1 kinaseJanus kinase 1Lamina PropriaLipopolysaccharidesLymphoid CellMacrophageMeasuresMediatingMesalamineMesalazineMetabolic ProcessesMetabolismMetagenomicsMiceMice MammalsModelingModern ManMononuclearMucosaMucosal Immune ResponsesMucosal TissueMucous MembraneMurineMusMyeloid CellsMφNKSFNative ImmunityNatural ImmunityNatural Killer Cell Stimulatory FactorNon-Polyadenylated RNANon-Specific ImmunityNonspecific ImmunityNutritionPathogenesisPathologyPathway interactionsPatientsPentasaPersonsPhagocytesPhagocytic CellPhenotypePhosphatesPhosphorylationPhysiopathologyPlasmaPlasma SerumPolymersPolyphosphate kinasePolyphosphatesProcessProductionProtein PhosphorylationProteomePublishingRNARNA Gene ProductsRag1Rag1 MouseRecombinantsReportingReticuloendothelial System, Serum, PlasmaRibonucleic AcidRoleRowasaSTAT proteinSTAT1STAT1 geneSTAT91SamplingSepsisSerumSeveritiesSeverity of illnessShapesSignal PathwaySignal Transducer and Activator of TranscriptionSignal TransductionSignal Transduction SystemsSignalingSingle cell seqSplenocyteSurfaceT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-CellsT-LymphocyteT-cell therapeuticsT-cell transfer therapyT8 CellsT8 LymphocytesTherapeuticTissuesTitrationsTyrosine-Protein Kinase JAK1Ulcerated ColitisUlcerative ColitisUnited StatesVirulenceWeight LossWeight Reductionadaptive immunityadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyalimentary tractamebocytebiobankbiological adaptation to stressbiological signal transductionbiorepositorybody weight lossbowelbowel inflammationcell typeclinical relevanceclinically relevantcohortcytokinedata registrydevelopmentaldigestive canaldigestive tract microbiomedisease controldisease modeldisease severitydisease subgroupsdisease subtypedisorder controldisorder modeldisorder subtypedrivingdysbacteriosisdysbiosisdysbioticeleocolitisenteric microbiomeepigenomeexperimentexperimental researchexperimental studyexperimentsgastrointestinal microbiomegut inflammationgut microbiomegut-associated microbiomehealth care burdenhuman datahuman diseasehypoimmunityimmune deficiencyimmune evasiveimmunodeficiencyin vivoinflamed bowelinflamed gutinflamed intestineinflammatory disease of the intestineinflammatory disorder of the intestineinjury to tissueinorganic phosphateinsightintestinal autoinflammationintestinal biomeintestinal inflammationintestinal microbiomeintestine diseaseintestine disorderm-Aminosalicylic Acidmeta-Aminosalicylic Acidmetatranscriptomicsmicrobial consortiamicrobial floramicrobial imbalancemicrobiomemicrobiotamicrofloramouse modelmulti-modalitymultimodalitymultiomicsmultiple omicsmultispecies consortiamurine modelmutantnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpanomicspathobiontpathogenpathophysiologypathwaypolymerpolymericpolyphosphate synthetaseprofessorprotein foldingreaction; crisisregional enteritisresponsesingle cell next generation sequencingsingle cell sequencingsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstress responsestress; reactiontherapeutic T-cell platformthymus derived lymphocytetissue injurytranslational studywt-loss
Description preview
Project Summary: The gastrointestinal tract hosts a substantial microbiota reservoir that supports processes
like nutrition, metabolism, immune development, and defense against pathogens. However, an imbalance in the
microbiota that favors pathobionts can augment inflammation, tissue injury, and pathologies such as
inflammatory bowel disease…
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