grant
Deciphering Pancreatitis Microenvironment through Intravital Imaging
Organization MAYO CLINIC JACKSONVILLELocation JACKSONVILLE, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025AddressAffectAnimal ModelAnimal Models and Related StudiesAnimalsAnticoagulationBlood flowBody TissuesCF2RCell BodyCellsCellular injuryClinical TrialsClottingCoagulationCoagulation ProcessDeath RateDevelopmentDiseaseDisorderDrug DeliveryDrug Delivery SystemsDrug ModelingsDrug PrecursorsDrugsDysfunctionEndothelial CellsEngineeringExhibitsExposure toF2RF2R geneFailureFormulationFoundationsFunctional disorderFutureGastrointestinal DiseasesGenesGeneticGenetic ModelsHealth Care CostsHealth Care SystemsHealth CostsHospital AdmissionHospitalizationHumanImaging technologyIn VitroInflammatoryInpatientsIntravenousIsoformsKO miceKnock-out MiceKnockout MiceKnowledgeLeadLocationMedicationMiceMice MammalsMicrocirculationModelingModern ManMonitorMurineMusNull MouseOutcomePAR1PancreasPancreaticPancreatic enzymePancreatitisPathogenesisPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPb elementPermeabilityPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhysiopathologyPlayPre-Clinical ModelPreclinical ModelsPreventionPro-DrugsProdrugsProtein IsoformsReceptor ProteinResearchResearch ProposalsRoleSafetySeveritiesSiteSolidTestingThrombaseThrombinTimeTissuesTransgenic MiceTreatment EfficacyTripcellimTrypsinTrypsin InhibitorsWorkacute pancreatitiscell damagecell injurycellular damagecombatcontinuous monitoringcostdamage to cellsdesigndesigningdevelopmentaldrug/agenteffective therapyeffective treatmentfibrinogenasegastrointestinalgastrointestinal disordergenetic approachgenetic strategyheavy metal Pbheavy metal leadhospitalization ratesimaging systemimprovedinhibitorinjury to cellsintervention efficacyintra-vital imagingintravital imaginglocal drug deliverymodel of animalmortality ratemortality ratiomouse modelmulti-photonmurine modelnovelpancreas enzymepathophysiologypathwaypatient oriented outcomespharmaceuticalpharmacologicpreventpreventingprotein expressionreceptorrecruitsocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic efficacytherapeutic evaluationtherapeutic testingtherapy efficacy
Description preview
PROJECT SUMMARY
Acute pancreatitis (AP) is a prevalent gastrointestinal condition that leads to a significant number of
hospitalizations and high healthcare costs. With no effective therapy currently available, there is an urgent
need for research to develop successful treatments. This proposal aims to investigate the roles of trypsin
and…
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