grant
Deciphering novel UPS regulation of Sgf73/ataxin-7 in controlling SAGA and associated functions in gene expression
Organization SOUTHERN ILLINOIS UNIVERSITY CARBONDALELocation CARBONDALE, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY202520S Catalytic Proteasome20S Core Proteasome20S Proteasome20S ProteosomeAPF-1ATP-Dependent Proteolysis Factor 1AddressBaker's YeastBasal Transcription FactorBasal transcription factor genesBrewer's YeastCancersCarboxypeptidase GCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessCellular RegulationChromatinClinical ResearchClinical StudyComplexConjugaseDiseaseDisorderE3 LigaseE3 Ubiquitin LigaseEnzyme GeneEnzymesEsteroproteasesEye diseasesFolacin ConjugaseFolate ConjugaseFolate Hydrolyzing EnzymeFolyl Conjugate SynthetaseFolyl Poly-gamma-Glutamate CarboxypeptidaseFolyl Polyglutamate Cleavage EnzymeFolylpolyglutamate HydrolaseFundingFutureGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGoalsHMG-20HealthHigh Mobility Protein 20Histone AcetylaseHistonesHumanLinkMacropainMacroxyproteinaseMaintenanceMalignant NeoplasmsMalignant TumorModern ManModificationMulticatalytic ProteinaseNational Institutes of HealthNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersPathogenesisPeptidasesPeptide HydrolasesPhysiologicPhysiologicalProcessProsomeProtease GeneProteasesProteasomeProteasome Endopeptidase ComplexProteinasesProteinsProteolytic EnzymesProteosomePteroyl Polyglutamate HydrolaseRNA ExpressionRegulationResearchRestRoleS cerevisiaeS. cerevisiaeSAGASCA7 proteinSPT/ADA/Gcn5 AcetyltransferaseSaccharomyces cerevisiaeSiteSubcellular ProcessSystemTherapeutic InterventionTranscriptionTranscription ActivatorTranscription CoactivatorTranscription Factor CoactivatorTranscription Factor Proto-OncogeneTranscription InitiationTranscription factor genesTranscriptional Activator/CoactivatorTranscriptional ControlTranscriptional RegulationUbiquitinUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3United States National Institutes of HealthWorkYeastsataxin-7cBioPortalcancer biomarkerscancer markerscell growth regulationcellular pathologychromatin modificationde-ubiquitinasede-ubiquitinating enzymedisease modeldisorder modelexperienceexperimentexperimental researchexperimental studyexperimentseye disordergamma-Glutamyl Hydrolasegenome integritygenomic integrityhistone acetyltransferasehuman modelintervention therapymRNA Exportmalignancymodel of humanmulticatalytic endopeptidase complexneoplasm/cancerneurological diseasenovelocular diseaseocular disorderophthalmopathypromoterpromotorsocial rolespinocerebellar ataxia 7 proteintargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic agent developmenttherapeutic developmenttranscription factorubiquitin isopeptidaseubiquitin-protein ligaseubiquitin-specific isopeptidase
Description preview
ABSTRACT:
Sgf73/ataxin-7 is a key component of an evolutionarily conserved transcriptional co-activator SAGA
(Spt-Ada-Gcn5-Acetyltransferase) with two distinct enzymatic activities for chromatin modifications, and is
up- and downregulated in cancer and other diseases such as eye and neurological disorders. Therefore, it
is crucial to understand…
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