grant
Deciphering Novel Principles of Rapid Proteostatic Control and Innovating Spatiotemporal Lysosomal Tools
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 20 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY202520S Catalytic Proteasome20S Core Proteasome20S Proteasome20S ProteosomeAPF-1ATP-Dependent Proteolysis Factor 1AddressAmino Acid SequenceAreaArginineAutoregulationBiologyCell BodyCellsCommunitiesComplexCytosolE3 LigaseE3 Ubiquitin LigaseEnzyme GeneEnzymesEukaryotic CellGeneralized GrowthGoalsGrowthHMG-20High Mobility Protein 20HomeostasisInvestigatorsKnowledgeL-ArginineLysosomesMacropainMacroxyproteinaseMetabolic PathwayMetabolic Protein DegradationMethylationModelingMolecularMulticatalytic ProteinaseOrganismPathway interactionsPeptidesPhysiological HomeostasisPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPrimary Protein StructureProcessProliferatingProsomeProteasomeProteasome Endopeptidase ComplexProtein BiosynthesisProtein CleavageProtein ModificationProtein TurnoverProteinsProteolysisProteomeProteosomeRegulationRegulatory Protein DegradationResearchResearch PersonnelResearch ResourcesResearchersResourcesRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinStimulusSubstrate SpecificitySystemTestingTissue GrowthUbiquitinUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3Workbiological researchfield based datafield learningfield studyfield testimprovedinnovateinnovationinnovativeinsightlife spanlifespanliving systemlysosomal proteinsmulticatalytic endopeptidase complexnovelontogenypathwaypreventpreventingprotein degradationprotein sequenceprotein synthesispublic data basepublic databasepublicly accessible data basepublicly accessible databasepublicly available data basepublicly available databaseresponsespatial and temporalspatial temporalspatiotemporaltooltraffickingubiquitin-protein ligase
Description preview
PROJECT ABSTRACT
Proteome integrity is maintained by a complex network that regulates protein synthesis, folding,
transport, and degradation. Lysosomes are the catabolic center of a cell and central to
maintaining proteome homeostasis by preventing, detecting, and removing abnormal proteins.
Major knowledge gaps remain in the regulation,…
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