grant
Deciphering long-term virus evolution through the reconstruction of past viral genomes
Organization FRED HUTCHINSON CANCER CENTERLocation SEATTLE, UNITED STATESPosted 17 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoVAIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAcute PoliomyelitisAddressAirway infectionsBritish IslesCOVID-19 virusCOVID19 virusCalibrationCausalityCell BodyCellsCoV-2CoV2CollectionComplementComplement ProteinsDNADNA VirusesDeoxyribonucleic AcidDevelopmentDiseaseDisease OutbreaksDisorderDocumentationDouble-Stranded DNAEBOVEbola virusEbola-like VirusesEpidemicEtiologyEvolutionFamilyForensic MedicineForensicsFutureGenomeGenomicsGoalsGreat BritainHIVHistoryHumanHuman Immunodeficiency VirusesImmunologyIndividualIndustrializationInfluenza AInfluenza A virusInfluenza Viruses Type AInfluenzavirus AKnowledgeLAV-HTLV-IIILeadLife CycleLife Cycle StagesLinkLymphadenopathy-Associated VirusMeaslesMedicalMethodologyMexicoModelingModern ManModernizationMolecularMorbidityMorbidity - disease rateMuseumsNon-Polyadenylated RNAOrthoebolavirusOrthomyxovirus Type AOutbreaksPaleontologyPathogenesisPathogenicityPathologyPb elementPolioPoliomyelitisPopulationPositionPositioning AttributePreventative strategyPrevention strategyPreventive strategyPropertyProteomicsProtocolProtocols documentationRNARNA Gene ProductsRNA VirusesRecording of previous eventsRecordsResearchResearch SpecimenRespiratory InfectionsRespiratory Tract InfectionsRibonucleic AcidRubeolaSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SamplingSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2SmallpoxSpainSpecimenSymptomsTechniquesTransmissionType A InfluenzaVariantVariationVariolaViralViral DiseasesViral Gene ProductsViral Gene ProteinsViral GenesViral GenomeViral ProteinsVirulentVirusVirus DiseasesVirus-HIVWorkWuhan coronaviruscareercausationclinical significanceclinically significantcomplementationcoronavirus disease 2019 viruscoronavirus disease-19 virusdevelopmentaldisease causationds-DNAdsDNAhCoV19heavy metal Pbheavy metal leadhistorieshuman pathogenidentification of virusesimprovedinnovateinnovationinnovativelife courselung preservationmicrobes genomemicrobial genomemolecular clockmorbillimortalitymultidisciplinarynCoV2new approachesnovel approachesnovel strategiesnovel strategypaleontological applicationspandemicpandemic diseasepast epidemicpathogenpathogenic viruspost-doctoral trainingprevious epidemicprior epidemicprotein functionreconstructionskillssmall poxsocio-economicsocio-economicallysocioeconomicallysocioeconomicssymptomatologysynergismtech developmenttechnology developmenttissue tropismtransmission processvariola majorviral RNAviral disease outbreakviral epidemicviral infectionviral outbreakviral pandemicviral pathogenvirologyvirus RNAvirus disease outbreakvirus genomevirus identificationvirus infectionvirus pathogenvirus proteinvirus-induced disease
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Project Summary
Viruses have imposed a significant global burden of morbidity and mortality for millennia. Just in the last
century, highly pathogenic RNA viruses such as influenza A, HIV and SARS-CoV-2 resulted in devastating
pandemics that directly impacted millions of individuals and altered socioeconomic dynamics worldwide.
Fueled by major…
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