grant
Deciphering interactions between human T cells and cardiomyocytes in immune checkpoint inhibitor-related myocarditis
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025Adrenal Cortex HormonesAdvisory CommitteesAffectAntigensAutoantigensAutologous AntigensAutomobile DrivingAwardBiologic ModelsBiological ModelsBiologyBlood SampleBlood specimenBody TissuesCancer PatientCancersCardiacCardiac Muscle CellsCardiac MyocytesCardiac alpha-MyosinCardiac α-MyosinCardiocyteCell BodyCellsCessation of lifeCheckpoint inhibitorClinical TrialsClone CellsCo-cultureCocultivationCocultureCoculture TechniquesCombined Modality TherapyCorticoidsCorticosteroidsDF/HCCDana-Farber Cancer InstituteDangerousnessDataDeathDevelopmentDevelopment PlansDrug TargetingEnvironmentFibroblastsFundingGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGeneral HospitalsGenesGoalsGuidelinesHeartHeart Muscle CellsHeart myocyteHematologyHumanImmuneImmune checkpoint inhibitorImmunesImmunooncologyImmunosuppressantsImmunosuppressive AgentsImmunosuppressive drugImmunosuppressive treatmentIn VitroIncidenceInflammationInvestigatorsLifeMHC ReceptorMajor Histocompatibility Complex ReceptorMalignant NeoplasmsMalignant TumorMassachusettsMediatingMedicineMentorsMissionModel SystemModelingModern ManMultimodal TherapyMultimodal TreatmentMyocarditisMyosin V1OncologyOncology CancerOrganOutcomePathogenesisPathogenicityPathologicPathologyPatientsPhysiciansPopulationPreventionProteinsPublic HealthRecommendationResearchResearch PersonnelResearch SpecimenResearchersSamplingScientistSelf ToleranceSelf-AntigensSpecimenStructureSystemT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell infiltrationT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-Cell Antigen ReceptorsT-Cell ReceptorT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT-cell therapeuticsT-cell transfer therapyTask ForcesTechniquesTechnologyTestingTherapeuticTimeTissuesTnITrainingTranscript Expression AnalysesTranscript Expression AnalysisTroponin ITroponin TTumor CellTumor ImmunityVentricular Cardiac alpha-MyosinVentricular alpha-MyosinWild Type MouseWorkadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyadvisory teamalpha-Myosinanalyze gene expressionanti-tumor immune responseanti-tumor immunityantitumor immunityautoreactive T cellcancer immunitycardiac inflammationcardiomyocytecareer developmentcell killingcell typeclinical trial protocolcombination therapycombined modality treatmentcombined treatmentconferenceconventiondesigndesigningdevelopmentaldrivingefficacy testingexperiencegene expression analysisgene expression assayhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshuman modelhuman tissueimmune check point inhibitorimmune suppressive agentimmune suppressorimmune-mediated adverse eventsimmune-oncologyimmune-related adverse effectimmune-related adverse eventsimmune-related adverse reactionimmuno oncologyimmunogenimmunology oncologyimmunosuppressive substanceimmunosuppressorin vitro Modelinduced human pluripotent stem cellsinhibitory troponin Iinnovateinnovationinnovativeinsightinstructormalignancymedical collegemedical schoolsmodel of humanmulti-modal therapymulti-modal treatmentneoplasm/cancerneoplastic cellnoveloncoimmunologypreservationpreventpreventingprogramsrecruitscRNA sequencingscRNA-seqschool of medicineself-reactive T cellside effectsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskillssummitsymposiasymposiumtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic T-cell platformtherapeutic targetthymus derived lymphocytetraffickingtranscriptional profilingtreatment strategytropomyosin binding protein troponin Ttumorwildtype mouseα-Myosin
Description preview
PROJECT SUMMARY
Severe immune-related adverse events (irAEs) such as immune checkpoint inhibitor-related myocarditis
(irMyocarditis) are poorly understood and potentially life-threatening side effects caused by immune checkpoint
inhibitors (ICIs). Steven Blum, MD is an Instructor of Medicine at Harvard Medical School and an Assistant in
Medicine…
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