grant
Deciphering innate and adaptive immune responses to Rickettsia parkeri
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 20 Jun 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025APF-1ATP-Dependent Proteolysis Factor 1AmericasAnabolismAnti-Bacterial AgentsAntibodiesAntigen TargetingAntigensAttenuatedAutophagocytosisB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBacterial O AntigenCapsulesCaspaseCaspase GeneCell BodyCell-Death ProteaseCellsCellular biologyClinicalComplementComplement ProteinsCysteine EndopeptidasesCysteine ProteaseCysteine ProteinasesCytosolDehydrogenasesDiseaseDisorderE3 LigaseE3 Ubiquitin LigaseEC 2.1.1Electron MicroscopyEnabling FactorsEndothelial CellsGeneralized GrowthGenesGeneticGenetic ScreeningGlycansGrowthHMG-20High Mobility Protein 20HumanICE-like proteaseImmuneImmune EvasionImmunesImmunityImmunologic FactorsImmunological FactorsIncidenceInfectionInflammasomeInnate Immune ResponseInnate ImmunityL-LysineLeftLipopolysaccharidesLysineMacrophageMeasuresMediatingMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMethylationMethyltransferaseMiceMice MammalsModelingModern ManMolecularMurineMusMutateMφNative ImmunityNatural ImmunityNatureNon-Specific ImmunityNonspecific ImmunityNorth AmericaO AntigensO-Specific PolysaccharidesOxidoreductaseOxidoreductase GenePathogenesisPathogenicity FactorsPathway interactionsPlayPolysaccharidesProtein BiochipsProtein ChipsProtein MethylationProtein MicroarrayProtein MicrochipsR parkeriR rickettsiiR. parkeriR. rickettsiiReductasesRickettsiaRickettsia InfectionsRickettsia parkeriRickettsia rickettsiiRickettsial Infectious DiseaseRickettsial Infectious DisorderRickettsialesRickettsiales diseaseRickettsiosisRocky Mountain Spotted FeverRoleSao Paulo TyphusSouth AmericaSurfaceSurface ProteinsSystemT-CellsT-LymphocyteTherapeuticTimeTissue GrowthTransferaseTransferase GeneTyphusUbiquitinUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3United StatesVaccine AntigenVaccinesVirulence FactorsWorkacute infectionadaptive immune responseadaptive immunityanti-bacterialattenuateattenuatesautophagybacteria pathogenbacterial pathogenbiosynthesiscapsulecell biologycomplementationcystein proteasecystein proteinasecysteine endopeptidasedesigndesigninggenetic approachgenetic strategygenome scalegenome-widegenomewidehuman diseaseimmune evasiveimmunogenimmunologic substanceimmunological substanceimprovedin vivoinnovateinnovationinnovativeinsightluminescencemethyl groupmethylasemutantnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynew vaccinesnext generation therapeuticsnext generation vaccinesnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapynovel vaccinesontogenypathogenpathogenic bacteriapathwaypreventpreventingresponserickettsial diseasescreen timescreeningscreeningssocial rolespotted feversuper high resolutionsuperresolutiontelevision watchingthymus derived lymphocytetick-bornetickbornetransmethylasetv watchingubiquitin-protein ligaseultra high resolutionvaccine candidate
Description preview
PROJECT SUMMARY/ABSTRACT
Tick-borne Rickettsia species cause serious human disease in the United States and worldwide, including
spotted fever and typhus, with no approved vaccines and an increasing incidence of infection. R. rickettsii is the
causative agent of Rocky Mountain spotted fever, and the closely related R. parkeri causes spotted fever…
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