grant
Deciphering enhancer regulation in stem cells
Organization CASE WESTERN RESERVE UNIVERSITYLocation CLEVELAND, UNITED STATESPosted 1 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AOF2AreaCancersCell BodyCell DifferentiationCell Differentiation processCellsChromatinDevelopmentDiseaseDisorderEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEnhancersEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGenesHealthHigher Order Chromatin FoldingHigher Order Chromatin StructureHigher Order StructureHistonesHumanKDM1AKDM1A geneKnowledgeLSD1LaboratoriesLysine-Specific Demethylase 1Lysine-Specific Demethylase 1AMalignant NeoplasmsMalignant TumorModern ManOrganism-Level ProcessOrganismal ProcessPathogenesisPhysiologic ProcessesPhysiological ProcessesPlayPluripotent Stem CellsProgenitor CellsProteinsReaderRegulationResearchRoleTranscriptional ControlTranscriptional Regulationantagonismantagonistcellular differentiationdevelopmentaldevelopmental diseasedevelopmental disorderepigeneticallyhistone H3 methyltransferasehistone demethylasehistone methylasehistone methyltransferasehuman diseaseinsightmalignancyneoplasm/cancernovelpluripotencypluripotency factorpluripotent progenitorpluripotent stateprogenitor cell differentiationprogenitor cell regenerationprogenitor cell self renewalprogenitor differentiationprogenitor regenerationprogenitor self renewalrecruitself-renewself-renewalsocial rolespatial and temporalspatial temporalspatiotemporalstem and progenitor cell regenerationstem and progenitor cell self renewalstem and progenitor differentiationstem cell differentiationstem cell regenerationstem cell self renewalstem cells
Description preview
Project Summary
The hallmark of pluripotent stem cells (PSCs) is their capability to self-renew and differentiate, which is governed
by the core pluripotency circuitry consisting of pluripotency factors OCT4, SOX2, and NANOG. Enhancers are
fundamental in regulating the spatial and temporal expression of pluripotency genes and lineage specific…
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