grant
Deciphering Cellular Heterogeneity and Inheritability in Migration
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 1 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025Basal Transcription FactorBasal transcription factor genesBiological MarkersBody TissuesCXC-R4CXCL12CXCL12 geneCXCL12 proteinCXCR-4CXCR4CXCR4 geneCell BodyCell Communication and SignalingCell LocomotionCell MigrationCell Migration AssayCell MovementCell SignalingCellsCellular MigrationCellular MotilityCharacteristicsChemokine (C-X-C Motif) Ligand 12ChemotaxisCuesD2S201EDataEarEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentFB22FailureGeneral Transcription Factor GeneGeneral Transcription FactorsGoalsHM89HSY3RRHereditaryHeterogeneityIn VitroIndividualInflammationInflammatory ResponseInheritedIntracellular Communication and SignalingLAP3LCR1LESTRLiquid substanceMalignant CellMeasurementMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsMicrofluidicsMigration AssayModelingMolecularMolecular Dynamics SimulationMotilityMovementMurineMusNPY3RNPYRNPYRLNPYY3RNatureNeoplasm MetastasisOrganellesOrganism-Level ProcessOrganismal ProcessPBSFPatternPhysiologic ProcessesPhysiological ProcessesPopulationPre-B Cell Growth Stimulating FactorProcessReporterRetrievalRoboticsSCYB12SDF-1SDF-1ASDF-1BSDF-1alphaSDF1SDF1ASDF1BSdf1 proteinSecondary NeoplasmSecondary TumorSignal TransductionSignal Transduction SystemsSignalingSkinSpeedStimulusStromal Cell-Derived Factor 1TLSF-ATLSF-BTPAR1TechnologyTestingTimeTissuesTranscription Factor Proto-OncogeneTranscription factor genesTreatment PeriodWound Repairangiogenesisbio-markersbiologic markerbiological signal transductionbiomarkerbody movementcancer cellcancer metastasiscell dimensioncell motilitycopy number alterationfluidhIRHimage processingin vivoinjury and repairintra-vital microscopyintravital microscopyliquidmigrationmolecular dynamicsmulti-photonresponsesingle cell analysisstromal cell-derived factor-1alphatherapeutic targettranscription factortreatment daystreatment durationtumor cell metastasiswound healingwound recoverywound resolutionµfluidic
Description preview
The overarching goal of our lab is to decipher cellular heterogeneity, dynamics, and inheritability using high-
throughput and longitudinal single-cell analysis. Specifically, we will focus on chemotaxis toward CXCL12 as a
model. Cell migration is an essential process in embryogenesis, angiogenesis, wound healing, inflammation,
and cancer…
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