grant
Deciphering Borrelia burgdorferi RpoS regulatory networks in ticks and mammals
Organization UNIVERSITY OF CONNECTICUT SCH OF MED/DNTLocation FARMINGTON, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025AffectAllelesAllelomorphsArthropod VectorsB burgdorferiB. burgdorferiBacteria KatF proteinBacteria rpoS proteinBacteria sigma factor 38 proteinBacteria sigma factor KatF proteinBacteria sigma factor S proteinBorreliaBorrelia burgdorferiBorrelia burgdorferi sensu strictoBorrelia oxidative stress regulatorBorreliella burgdorferiBosRCell Communication and SignalingCell SignalingComplexDNA BindingDNA Binding InteractionDNA boundDNA-Dependent RNA PolymerasesDNA-Directed RNA PolymeraseDataDifferential Gene ExpressionDiseaseDisorderDisparateDissociationE coliE. coliEpidemicEscherichia coliGatekeepingGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenesGenetic TranscriptionHoloenzymesHumanIPTGIn VitroInfectionIntracellular Communication and SignalingIntracellular Second MessengerInvestigationIsopropyl ThiogalactosideIxodesIxodes tickIxodidaLeadLicensingLife StyleLifestyleLigandsLyme BorreliosisLyme DiseaseLyme Disease SpirocheteMammaliaMammalsMediatingMiceMice MammalsMidgutModern ManMurineMusNatureNeedlesOrder SpirochaetalesOrganismPathway interactionsPb elementPhasePlayProteinsRNA ExpressionRNA PolymerasesRegulationRegulatory PathwayRegulonReportingRepressionRodentRodentiaRodents MammalsRoleRpoSSecond Messenger SystemsSecond MessengersShapesSigma ElementSigma FactorSigma Initiation FactorSigma SubunitSignal TransductionSignal Transduction SystemsSignalingSpirochaetalesSpirochetesTicksTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTranscriptionUnited StatesYawningarboviral diseasearbovirus diseasearthropod-borne diseasearthropodborne diseasebiological signal transductionblood mealborrelialcofactorenzooticexperimentexperimental researchexperimental studyexperimentsgatekeepergene functionglobal gene expressionglobal transcription profileheavy metal Pbheavy metal leadinsightliving systemlyme spirochetenovelpathwayposttranscriptionalpromoterpromotorprotein protein interactionresponsesigma(38) protein, Bacteriasigma(S) protein, Bacteriasignal transduction second messengerssocial roletick mediated transmissiontick transmissiontick transmittedtranscriptometranscriptomicsvectorvector tick
Description preview
Abstract
Borrelia burgdorferi (Bb) is maintained in nature within an enzootic cycle involving a mammalian reservoir host
and a tick vector. To sustain this dual-host lifestyle, Bb must remodel its transcriptome as it shuttles between
these two host milieus. The RpoN/RpoS pathway is central to borrelial gene regulation. In addition to
upregulating…
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