grant

Deciphering and predicting ecologically sensitive gut microbiome contributions to human metabolic health

Organization HARVARD UNIVERSITYLocation CAMBRIDGE, UNITED STATESPosted 1 Sept 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025AddressAffectAnimalsBody TissuesCaloric IntakeDevelopmentDietDietary InterventionEcological ChangeEnergy ExpenditureEnergy IntakeEnergy MetabolismEquityExerciseExhibitsFosteringFunctional MetagenomicsFutureGI microbiomeGerm-FreeHealthHealth BenefitHealth ServicesHumanHuman FigureHuman MicrobiomeHuman bodyIndividualIndustrializationIntermediary MetabolismLife StyleLifestyleMediatingMetabolicMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolismMetagenomicsMiceMice MammalsMicrobeModern ManModificationMurineMusNutrition InterventionsNutritional InterventionsOutcomePhenotypeResearchRiskShapesSocial NetworkSocial statusTestingThesaurismosisTimeTissuesTransmissionTransplantationVariantVariationWorkcaloric dietary contentdevelopmentaldiet interventiondietarydietsdigestive tract microbiomedisease riskdisorder riskenteric microbiomeexercise interventionexperimentexperimental researchexperimental studyexperimentsgastrointestinal microbiomegut microbiomegut-associated microbiomehost microbiomehuman-associated microbiomeintestinal biomeintestinal microbiomemachine learning based modelmachine learning modelmetabolism disordermetabolism measurementmetabolomicsmetabonomicsmicrobialmicrobiomemodifiable lifestyle factorsphysical activity interventionresilienceresilientsocialsocial contactsocial positionsocial standingtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttransmission processtransplant
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ABSTRACT
Metabolic health depends on acquiring an appropriate amount of energy and allocating it efficiently across tissues.

The human gut microbiome modulates energy acquisition and allocation and exhibits high sensitivity to modifiable

lifestyle factors such as diet, exercise, and social contact, resulting in gut microbiome contributions to…

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Deciphering and predicting ecologically sensitive gut microbiome contributions to human metabolic health — HARVARD UNIVE | Dev Procure