grant
DDX39a and Cellular Senescence
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY2025Age related pathologiesBiological FunctionBiological ProcessCell AgingCell SenescenceCellular AgingCellular ExpansionCellular GrowthCellular SenescenceEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFibroblastsGene TranscriptionGenetic TranscriptionHumanLinkLungLung Respiratory SystemModern ManModificationNon-Polyadenylated RNAPathologicPlayProcessProliferatingProteinsRHA enzymeRNARNA BindingRNA ExpressionRNA Gene ProductsRNA HelicaseRNA SplicingRNA boundRNA helicase ARNA metabolismReplicative SenescenceResearchRibonucleic AcidRoleSkinSplicingStructureTranscriptionTranslationsage associated pathologiesage dependent pathologiesage induced pathologiesagedaging associated pathologiesaging dependent pathologiesaging induced pathologiesaging pathologiesaging processaging related pathologiescell growthchromatin remodelingepigenetic regulationepigeneticallyglobal gene expressionglobal transcription profilenovelpreventpreventingreplicative agingsenescencesenescentsocial roletranscriptometranslation
Description preview
RNA helicases are a class of enzymes crucial for RNA metabolism, functioning to unwind RNA structures and facilitate processes such as transcription, splicing, and translation. These proteins have been implicated in multiple biological functions and pathological conditions. Despite their established importance, the specific roles of RNA helicases…
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