grant
Cytosolic SINE retrotransposable element cDNA and mitochondrial DNA in aging retina
Organization UNIVERSITY OF VIRGINIALocation CHARLOTTESVILLE, UNITED STATESPosted 15 Aug 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AD dementiaAffectAge related macular degenerationAge related pathologiesAge-Related MaculopathyAgingAlu ElementsAlu FamilyAlu Repetitive SequencesAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAnimalsBeta Proprotein Interleukin 1BindingBiogenesisBlindnessBody TissuesCell BodyCell Communication and SignalingCell DeathCell SignalingCell to Cell Communication and SignalingCell-Cell SignalingCellsCessation of lifeChromatinCognitiveCollaborationsComplementary DNAComplexCytoplasmDNADataDeathDeoxyribonucleic AcidDiseaseDisorderDysfunctionEC 2.7.7.49ElementsEpidemiologyEventEvolutionEyeEyeballFamilyFoundationsFunctional disorderFutureGenerationsGeneticGuanosineHumanIFN-Gamma-Inducing Factor GeneIFN-gamma-Inducing FactorIGIFIGIF GeneIL-1 GammaIL-1 Gamma GeneIL-1 betaIL-1 βIL-1-bIL-18IL-18 GeneIL-1gIL-1g GeneIL-1βIL1-BetaIL1-βIL18IL18 ProteinIL18 geneIL1B ProteinIL1F2IL1F4IL1F4 GeneIL1βInflammagingInflammasomeInflammationInflammatoryInnate Immune ResponseInterferon-Gamma-Inducing Factor GeneInterferon-gamma-Inducing FactorInterleukin 18 (Interferon-Gamma-Inducing Factor)Interleukin 18 (Interferon-Gamma-Inducing Factor) GeneInterleukin 18 ProproteinInterleukin 18 Proprotein GeneInterleukin 1betaInterleukin-1 GammaInterleukin-1 Gamma GeneInterleukin-1 betaInterleukin-18Interleukin-18 PrecursorInterleukin-18 Precursor GeneInterleukin-1βIntracellular Communication and SignalingJointsKnowledgeLibrariesLytotoxicityMGC12320MGC12320 GeneMapsMediatingMedicalMiceMice MammalsMitochondriaMitochondrial DNAMitochondrial PorinModern ManMolecularMolecular InteractionMurineMusNGS MethodNGS systemNon-Polyadenylated RNANuclearOrigin of LifeOuter pigmented layer of retinaPathogenesisPathologicPathologyPathway interactionsPhysiopathologyPigment cell layer of retinaPigmented layer of retinaPreinterleukin 1 BetaPrimary Senile Degenerative DementiaProductionPropertyRNARNA Gene ProductsRNA TranscriptaseRNA-Dependent DNA PolymeraseRNA-Directed DNA PolymeraseRegulationRetinaRetinal Pigment EpitheliumRetinal pigment epithelial cellsRetrotransposonReverse TranscriptaseReverse TranscriptionRevertaseRibonucleic AcidRoleSightSignal TransductionSignal Transduction SystemsSignalingSterilityStimulusStructure of retinal pigment epitheliumTLR proteinTestingTherapeuticTissuesToll-Like Receptor Family GeneToll-like receptorsToxic effectToxicitiesVDAC mitochondrial porinVDAC proteinsVisionVisualVoltage-Dependent Anion Channelage associated effectsage associated pathologiesage dependent macular degenerationage dependent pathologiesage effectage induced macular degenerationage induced pathologiesage related effectsage related macular diseaseage related macular dystrophyage-related inflammationagedaging associated diseaseaging associated disordersaging associated inflammationaging associated pathologiesaging dependent pathologiesaging effectaging induced pathologiesaging pathologiesaging related diseaseaging related disordersaging related pathologiesanion-selective channels voltage-dependentbiological signal transductioncDNAcell typecytotoxiccytotoxicitydisease associated with agingdisease of agingdisorder of agingdisorders associated with agingdisorders related to agingenhance healthspanepidemiologicepidemiologicalextend healthspanextending healthy lifespaneye toxicitygeographic atrophyhallmarks of aginghealthspanhealthspan extensionhealthy life spanhuman diseaseimpact of ageimprove healthspanimprovedincrease healthspaninflamm-ageinginflamm-aginginflammation associated with aginginfluence of ageinsightintercellular communicationmicronucleusmitochondria porinsmitochondrialmitochondrial dysfunctionmitochondrial pore proteinmtDNAnecrocytosisnext gen sequencingnext generation sequencingnextgen sequencingnovelocular toxicitypathophysiologypathwaypillars of agingpore forming protein VDACprimary degenerative dementiapro-agingprogeronicprolong healthspanpromote agingpromote healthspanretinal toxicitysenile dementia of the Alzheimer typesenile macular diseasesensorsocial rolesteriletissue degenerationvision lossvisual functionvisual lossvoltage-dependent, anion-selective, channel forming protein, mitochondrial
Description preview
PROJECT SUMMARY
The retinal pigmented epithelium (RPE) is an amitotic, long-lived cell type that supports healthy visual function
for numerous decades. The aging retina displays pathologic features that are exaggerated in a complex disease
called age-related macular degeneration (AMD). Progressive degeneration of the aging RPE is a hallmark of…
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