grant
Cytoskeletal Function in C. elegans Embryos
Organization UNIVERSITY OF OREGONLocation EUGENE, UNITED STATESPosted 1 Jun 2019Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AnimalsAtomic Force MicroscopyAuxinsBiologic ModelsBiological ModelsBlastomereBypassC elegansC. elegansC.elegansCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCaenorhabditis elegansCancersCas nuclease technologyCell BodyCell divisionCellsCellular MatrixChimera ProteinChimeric ProteinsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCytoskeletal SystemCytoskeletonDNA mutationEmbryoEmbryonicEssential GenesFecundabilityFecundityFertilityForce MicroscopyFusion ProteinGenesGeneticGenetic ChangeGenetic defectGenetic mutationGoalsHumanInvestigationLaboratoriesM PhaseMalignant NeoplasmsMalignant TumorMeiosisMicro-tubuleMicrotubulesMitosisMitosis StageModel SystemModelingModern ManMolecular GeneticsMutationNematodaNematodesOocytesOvocytesProcessProteinsRegulationResearchResolutionRoleScanning Force MicroscopyTemperatureTissue Engineeringbioengineered tissuebiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiescell cortexembryo stage 2engineered tissuegene functiongene replacementgenetic approachgenetic strategygenome mutationin vivointracellular skeletonlight microscopylive cell imagelive cell imaginglive cellular imagelive cellular imagingmalignancymeioticmodel organismneoplasm/cancernovelprogramsresolutionsroundwormsocial role
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Project Summary
For 30 years now, our laboratory has used live cell imaging with fluorescently marked proteins,
and classical and molecular genetic approaches with the early embryo of the nematode
Caenorhabditis elegans to investigate cytoskeletal function and regulation. In addition to having
isolated temperature-sensitive mutations in many…
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