grant
Cytokinesis and the Septin Cytoskeleton
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AD dementiaActomyosinAddressAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaArchitectureBacterial InfectionsBasic ResearchBasic ScienceBiochemicalBiologyBudding YeastCancersCannot achieve a pregnancyCell BodyCell CycleCell DifferentiationCell Differentiation processCell Division CycleCell FunctionCell Growth in NumberCell LocomotionCell MigrationCell MovementCell MultiplicationCell PhysiologyCell ProcessCell ProliferationCellsCellular FunctionCellular MatrixCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCellular ProliferationCytokinesisCytoplasmic DivisionCytoskeletal SystemCytoskeletonDataDefectDegenerative Neurologic DisordersDendritic SpinesDifficulty conceivingDiffusionDiseaseDisorderEndomycetalesEngineering / ArchitectureEventEvolutionFission YeastGeneticHigher Order Chromatin FoldingHigher Order Chromatin StructureHigher Order StructureImaging technologyInfertilityInherited NeuropathyIsoformsLifeMalignant NeoplasmsMalignant TumorMammalian CellMolecularMorphogenesisMyosin IIMyosin Type IINervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsOrganismParalysis AgitansParkinsonParkinson DiseasePlatinumPlatinum BlackPlayPrimary ParkinsonismPrimary Senile Degenerative DementiaProtein IsoformsPt elementPublic HealthPublishingRoleS pombeS. pombeSaccharomycetalesSchizosaccharomyces pombeSiteSpermiogenesisStereotyped BehaviorSubcellular ProcessTestingVesicleYeast Model Systembacteria infectionbacterial diseasecell behaviorcell motilitycellular behaviorcellular differentiationciliogenesiscilium biogenesisconstrictiondegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdendrite spinediffuseddiffusesdiffusingdiffusionsfertility cessationfertility losshereditary neuropathyhuman diseaseinfertileinsightintracellular skeletonliving systemmalignancymorphogenetic processneoplasm/cancerneurodegenerative illnessprimary degenerative dementiascaffoldscaffoldingsenile dementia of the Alzheimer typesocial rolesuperresolution microscopyyeast model
Description preview
Project Summary/Abstract:
Cytokinesis is fundamental to life, and the septins form cytoskeletal scaffolds or diffusion barriers of distinct
architectures to impact diverse cellular functions including cytokinesis, cell migration, ciliogenesis, dendritic
spine morphogenesis, spermiogenesis, and bacterial infection. Defects in cytokinesis or septins…
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