grant
Cystoscopy-augmenting tools to improve the sensitivity and specificity of detection of urothelial carcinoma in situ
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 19 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025Accuracy of DiagnosisActive Follow-upAdoptionAlgorithmsBiological MarkersBiopsyBladderBladder CancerBladder NeoplasmBladder TumorsBladder Urinary SystemBody TissuesBypassCalibrationCancer DetectionCancer TreatmentCancerousCancersCarcinoma in SituClinicalClinical effectivenessConfusionConfusional StateConsumptionContrast AgentContrast DrugsContrast MediaCystoscopesCystoscopyDataData SetDeath RateDetectionDiagnosisDiseaseDisease ProgressionDisorderDoppler OCTEquipmentFiberGoalsGuidelinesHealthHealth CareHealth Care CostsHealth CostsHistologyHistopathologyHospitalsHumanImageImaging ProceduresImaging TechnicsImaging TechniquesIndividualInflammationIntraepithelial CarcinomaInvadedLeftLesionLightLiteratureMachine LearningMalignant Bladder NeoplasmMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMalignant Tumor of the BladderMalignant neoplasm of urinary bladderMental ConfusionMicroscopicMissionModern ManMorbidityMorbidity - disease rateMuscleMuscle TissueNational Institutes of HealthNormal TissueNormal tissue morphologyOCT TomographyOperative ProceduresOperative Surgical ProceduresOptical Coherence TomographyPatientsPersonal SatisfactionPhotoradiationPreinvasive CarcinomaPublishingQOLQuality of lifeRadical CystectomyRadiopaque MediaRecommendationRecurrenceRecurrentRecurrent Malignant NeoplasmRecurrent Malignant TumorResearch SpecimenResectedResolutionRiskSavingsScanningSensitivity and SpecificitySpecific qualifier valueSpecificitySpecifiedSpecimenSpeedStaining methodStainsSurgicalSurgical InterventionsSurgical ProcedureTechniquesTechnologyTestingTimeTissuesTransitional CarcinomaTransitional Cell CarcinomaUnited States National Institutes of HealthUrinary Bladder CancerUrinary Bladder Malignant TumorUrinary Bladder NeoplasmUrinary Bladder TumorUrothelial CarcinomaVariantVariationactive followupanti-cancer therapybio-markersbiologic markerbiomarkercancer progressioncancer recurrencecancer therapycancer-directed therapyco-morbidco-morbiditycomorbiditycostdeep learningdeep learning methoddeep learning strategydemographicsdesigndesigningdetection sensitivitydiagnostic accuracydigitaldigital appdigital applicationsex vivo imagingfollow upfollow-upfollowed upfollowupimage translationimagingimaging probeimprovedin situ cancerinnovateinnovationinnovativemachine based learningmalignancymenmicroscope imagingmicroscopic imagingmicroscopy imagingmortalitymortality ratemortality ratiomulti-modalitymultimodalitymuscularneoplasm progressionneoplasm/cancerneoplastic progressionnon-muscle invasive bladder cancernoveloptic imagingoptical Doppler tomographyoptical coherence Doppler tomographyoptical imagingpreventpreventingresolutionsstandard of caresurgerytech developmenttechnology developmenttooltumor progressionurinary bladderwell-beingwellbeing
Description preview
ABSTRACT: Up to 75% of patients diagnosed with high-grade, non-muscle-invasive bladder cancer (BC) will
develop recurrences. Left undetected or untreated, recurrent bladder cancer leads to muscle invasion and
radical cystectomy, a major surgery with high morbidity and mortality. Thus, clinical guidelines recommend
surveillance every 3–12 months,…
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