grant
Cross-neuronal Structural Plasticity in Drosophila Motor Circuits
Organization TEXAS A&M UNIVERSITYLocation COLLEGE STATION, UNITED STATESPosted 1 Apr 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026AblationAddressAnimal ModelAnimal Models and Related StudiesApoplexyAutomobile DrivingAxonBrainBrain Nervous SystemBrain TraumaBrain Vascular AccidentCNS plasticityCalcium Ion SignalingCalcium SignalingCell BodyCell Communication and SignalingCell LocomotionCell MigrationCell MovementCell SignalingCellsCellular MigrationCellular MotilityCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCessation of lifeClinicalCognitionCognitive deficitsCompensationDataDeathDefectDendritesDrosophilaDrosophila genusEncephalonEnsureExcitatory SynapseExhibitsExocytosisGeneticGliaGlial CellsImpairmentInhibitory SynapseInjuryIntracellular Communication and SignalingInvertebrataInvertebratesInvestigationKnowledgeKolliker's reticulumLarvaLearningLocationLocomotionMammaliaMammalsMediatingMedical RehabilitationMemoryModelingMorphologyMotorMotor CellMotor NeuronsMuscleMuscle TissueMyoneural JunctionNGF ReceptorsNerve CellsNerve DegenerationNerve Growth Factor ReceptorsNerve Transmitter SubstancesNerve UnitNervous SystemNeural CellNeurocyteNeurogliaNeuroglial CellsNeurohumor ReceptorsNeurologic Body SystemNeurologic Organ SystemNeuromediator ReceptorsNeuromuscular JunctionNeuron DegenerationNeuronal PlasticityNeuronsNeuroregulator ReceptorsNeurotransmitter ReceptorNeurotransmittersNeurotrophic Factor ReceptorNeurotrophin ReceptorsNon-neuronal cellNonneuronal cellPathway interactionsPatternPhagocytosisPhaseProcessPropertyRecoveryRehabilitationRehabilitation therapyResearchRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSpinal Cord TraumaSpinal TraumaSpinal cord injuredSpinal cord injuryStrokeSynapsesSynapticSynaptic plasticityTestingTherapeuticTimeTraumatic Brain InjuryTraumatic MyelopathyVertebrate AnimalsVertebratesadverse consequenceadverse outcomeaxonal sproutingbiological signal transductionbrain attackbrain injury and spinal cord injurybrain/spinal cord injurycell motilitycentral nervous system plasticitycerebral vascular accidentcerebrovascular accidentcognitive defectscopingdesigndesigningdrivingfruit flyfunctional restorationimprovedinjuriesinjury recoveryinsightmodel of animalmotoneuronmotor impairmentmovement impairmentmovement limitationmuscularnerve cell deathnerve cell lossnerve cementnerve injuryneuralneural circuitneural circuitryneural degenerationneural injuryneural plasticityneurocircuitryneurodegenerationneurodegenerativeneurological degenerationneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal circuitneuronal circuitryneuronal deathneuronal degenerationneuronal lossneuronal survivalneuroplasticneuroplasticityneurotrophic factorneurotrophinneutrophinpathwayreceptor expressionrecovery after injuryrecovery following injuryrecovery post injuryrehab therapyrehabilitativerehabilitative therapyresponserestorationrestore functionrestore functionalityrestore lost functionsocial rolespinal cord and brain injurystroke recoverystrokedstrokessynapsesynaptic circuitsynaptic circuitrytooltraumatic brain damagevertebrata
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Project Summary
Damage to the nervous system results in the death of many neurons, leading to adverse outcomes such as
locomotor and cognitive defects. Neural injuries may induce neuroplasticity responses in surviving neurons,
where they extend their axons and dendrites and form new connections (undergo rewiring) to cope with the
loss of their…
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