grant
Critical Role of the Gut Microbiota in Prunes’ Prevention of Glucocorticoid Induced Osteoporosis
Organization MICHIGAN STATE UNIVERSITYLocation EAST LANSING, UNITED STATESPosted 6 Jul 2023Deadline 5 Jul 2028
NIHUS FederalResearch GrantFY2025AcidsAddressAdherenceAmazeApoptosisApoptosis PathwayBlood SerumBone DensityBone FormationBone Mineral DensityCancellous boneCell BodyCellsClinical TrialsComplementary HealthDataDietDiseaseDisorderDoseDrug TherapyDrugsDrynessFellowshipFiberFractureFruitGI microbiotaGastrointestinal microbiotaGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGlucocorticoidsHealthHealth Care CostsHealth CostsHumanIn VitroIncidenceIntegrative MedicineIntestinalIntestinesL-TryptophanLevotryptophanLinkLiteratureMediatingMedicationMiceMice MammalsMissionModelingModern ManMurineMusNCCAMNCCIHNational Center for Complementary and Integrative HealthNational Center for Complementary and Integrative MedicineNon-pharmacologic TherapyNonpharmacologic InterventionNonpharmacologic TherapyNonpharmacologic approachNonpharmacologic treatmentOsteoblastsOsteogenesisOsteoporosisOsteoporosis preventionOutcomeOutcome MeasurePathogenesisPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPlacebosPlayPlumPre-Clinical ModelPreclinical ModelsPreventionProbioticsProductionProgrammed Cell DeathRoleSafetyScienceSerumSham TreatmentTestingTrainingTranscript Expression AnalysesTranscript Expression AnalysisTryptophanTryptophan MetabolismTryptophan Metabolism Pathwayadherence rateaging preventionanalyze gene expressionanti aginganti geronicantiagingbonebone fracturebone healthbone tissue formationbone turnoverbowelcombatcostcost effectivedensitydietarydietary fruitdietsdrug interventiondrug treatmentdrug/agententeric microbial communityenteric microbiotafecal microbial transplantationfecal microbiome transplantationfecal microbiota transplantfecal microbiota transplantationfecal samplefecal transplantfecal transplantationfeedingfracture riskgastrointestinal microbial floragene expression analysisgene expression assaygut communitygut floragut healthgut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microflorahuman florahuman microbial communitieshuman microbiotahuman microflorahuman modelhuman-associated microbial communitieshuman-associated microbiotaimprovedin vivoin vivo Modelinnovateinnovationinnovativeintegrative healingintegrative healthintestinal floraintestinal microbiotaintestinal microfloraintestinal tract microflorameasurable outcomemetabolism measurementmetabolomicsmetabonomicsmicrobialmicrobial consortiamicrobial floramicrobiotamicrobiota compositionmicrofloramodel of humanmouse modelmultispecies consortiamurine modelnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapeuticsnew therapynew therapy approachesnew therapy targetnew treatment approachnew treatment strategynext generation therapeuticsnon-drug therapynon-drug treatmentnondrug therapynondrug treatmentnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy approachnovel therapy targetoutcome measurementpatient oriented outcomespharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspre-clinicalpreclinicalpreventprevent age relatedprevent agingprevent osteoporosispreventingprimary outcomeresponsesham therapyside effectsocial rolestool samplestool specimensubstantia spongiosasubstantia trabecularissuppress agingtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttrabecular bonetranscriptional profilingtransplant model
Description preview
PROJECT SUMMARY/ABSTRACT
Prolonged glucocorticoid use can lead to glucocorticoid induced osteoporosis (GIO) and subsequently increase
fracture risk in as little as three months. Current pharmacological therapies to combat GIO are effective,
however they carry significant side effect profiles and are costly, leading to historically poor adherence…
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