grant
CRISPR Tiling
Organization ST. JUDE CHILDREN'S RESEARCH HOSPITALLocation MEMPHIS, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAML1AMLCR1Amino AcidsAutomobile DrivingBiologic ModelsBiological ModelsCBFA2CRISPRCRISPR editing screenCRISPR libraryCRISPR screenCRISPR-based libraryCRISPR-based screenCRISPR/Cas systemCRISPR/Cas9 libraryCRISPR/Cas9 screenCancer CenterCancer ModelCancerModelCancersCell BodyCell Culture TechniquesCell Growth in NumberCell MultiplicationCell ProliferationCell modelCellsCellular ProliferationCellular modelChildhood CancersChromatinCitiesClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats libraryCodeCoding SystemConsultCustomDNA seqDNA sequencingDNAseqDataData AnalysesData AnalysisDiseaseDisorderElementsEnsureEpendymomaEvaluationExonsFamilyFusion Oncogene ProteinsGene ExpressionGenesGeneticGoalsHigh-Throughput Nucleotide SequencingHigh-Throughput SequencingIndividualKnowledgeLeadLibrariesMalignant CellMalignant Childhood NeoplasmMalignant Childhood TumorMalignant NeoplasmsMalignant Pediatric NeoplasmMalignant Pediatric TumorMalignant TumorMalignant childhood cancerMapsModel SystemModelingNFKB3OncogenicPAX5PAX5 genePEBP2A2PEBP2aBPb elementPeptide DomainPhysical condensationPopulationPositionPositioning AttributeProtein DomainsProtein RegionProteinsPublishingPuromicinaPuromycinPuromycinePuromycinumQuality ControlRELARELA geneRUNX1RUNX1 geneReportingResearch SupportResolutionRoleSamplingScanningSchemeStructural ModelsSystemTechnologyTertiary Protein StructureTestingTherapeuticTimeWHO Grade II Ependymal NeoplasmWHO Grade II Ependymal Tumoraminoacidanalysis pipelinecancer cellcancer in a childcancer in childrencell culturecell cultureschild with cancerchildhood malignancyclustered regularly interspaced short palindromic repeats screencomputational pipelinescondensationconsultscustomsdata analysis pipelinedata interpretationdata processing pipelinedensitydrivingendonucleaseexperimentexperimental researchexperimental studyexperimentsfusion oncoproteinheavy metal Pbheavy metal leadinnovateinnovationinnovativeinterestlentiviral-transducedlentivirally transducedlentivirus transducedleukemiamalignancyneoplasm/cancernovelpediatric cancerpediatric malignancyprogramsprotein functionresolutionssocial rolethree dimensional
Description preview
PROJECT SUMMARY- CORE 2
Fusion oncoproteins (FOs) enclose folded domains and intrinsically disordered regions (IDRs)
rearranged from fusion partner genes, contributing to condensate formation and oncogenic
transformation. Understanding of functional elements within FOs will elaborate on how FOs promote
aberrant gene expression and other types…
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