grant
CRISPR Generated Genomic Templates to Evaluate Epileptogenesis
Organization TEXAS A&M UNIVERSITY-KINGSVILLELocation KINGSVILLE, UNITED STATESPosted 1 Jun 2024Deadline 31 May 2028
NIHUS FederalResearch GrantFY20252 propylvalerateATP1A2ATP1A2 geneAffectAllelesAllelomorphsAmericanAnti-epilepticAntigenic DeterminantsAssayBCNG1Binding DeterminantsBioassayBiochemicalBiologicalBiological AssayBody TissuesBrain Cyclic-Nucleotide Gated 1Brain regionCRISPRCRISPR/Cas systemCarbamazepineCell BodyCell IsolationCell SegregationCell SeparationCell Separation TechnologyCellsCellular biologyChildhoodClustered Regularly Interspaced Short Palindromic RepeatsDNA mutationDevelopmentDiagnosisDilantinDiphenylhydantoinDiseaseDisorderDrosophilaDrosophila genusDrug TargetingEnhancersEpilepsyEpileptic SeizuresEpilepticsEpileptogenesisEpitolEpitopesEquilibriumExonsFHM2FenitoinFliesFutureGenerationsGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenomicsGoalsHCN1HCN1 geneHealthHepatic FailureHourHumanHyperpolarization-Activated Cyclic Nucleotide-Gated Potassium Channel 1IndividualInvestigationIon ChannelIonic ChannelsLeadLearningLethargiesLiver FailureMapsMembrane ChannelsMental DepressionMethodsModelingModern ManMosaicismMutationNerve CellsNerve UnitNervous System InjuriesNervous System TraumaNervous System damageNeural CellNeurocyteNeurological DamageNeurological InjuryNeurological traumaNeuronsNormal TissueNormal tissue morphologyOrganismOrthologOrthologous GeneOutcomePb elementPhenytoinPotassium Channel, Voltage-Gated, Brain, 1PredispositionPrevalencePreventionProcessPropertyProteinsProteomicsPublic HealthPumpRNA-Binding ProteinsReading FramesResearchResolutionRoleScienceSeizure DisorderSeizuresStudentsSusceptibilitySystemTegretolTestingTimeTissuesTransmissionUnderrepresented GroupsUnderrepresented PopulationsVariantVariationanti-epileptic agentsanti-epileptic drugsbalancebalance functionbiologiccell biologycell sortingchildhood epilepsycommon treatmentcustomized therapycustomized treatmentdepressiondevelop therapydevelopmentalearly onsetelectrical propertyepilepsiaepileptic encephalopathiesepileptogenicexperienceexperimentexperimental researchexperimental studyexperimentsflyfruit flygenome editinggenome mutationgenomic editinggraduate studentheavy metal Pbheavy metal leadhuman diseaseimprovedindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentinsightintervention developmentknock-downknockdownliving systemmosaicmosaic diseasesmosaic disordersmutantneuronalneurotraumapatient specific therapiespatient specific treatmentpediatricpediatric epilepsyprospectiverecombinaseremediationresolutionsside effectskillssocial roletailored medical treatmenttailored therapytailored treatmenttargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapy developmenttransmission processtreatment developmentunder representation of groupsunder represented groupsunder represented peopleunder represented populationsundergradundergraduateundergraduate studentunderrepresentation of groupsunderrepresented peopleunique treatmentusabilityvalproate
Description preview
Project Summary
In its most basic form, this proposal will explore the effects of human disease through the use of
a fly model to generate fly avatars of severe epileptic disease. The form of epilepsy that will be
modeled here is Developmental and Epileptic Encephalopathy (DEE)—a pediatric epileptic
condition that causes severe early onset…
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