grant

CRCNS: Dissection and control of cognitive thalamocortical dynamics

Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 5 Sept 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY202522q11Animal BehaviorAnimalsAttentionBehaviorBehavioralBiologicalCharacteristicsCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalCollaborationsComputational toolkitComputer ModelsComputerized ModelsConnectionist ModelsConnector NeuronDNA mutationDataData AnalysesData AnalysisDecision MakingDevelopmentDiseaseDisorderDisparateDissectionDisturbance in cognitionDysfunctionElectrophysiologyElectrophysiology (science)EnvironmentEquilibriumEsthesiaFoundationsFrequenciesFunctional disorderGeneticGenetic ChangeGenetic ModelsGenetic defectGenetic mutationHistoryHumanImmediate MemoryImpaired cognitionImpairmentInstructionIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronInterventionJointsKnowledgeLeadLinkLiteratureMachine LearningMental disordersMental health disordersMiceMice MammalsMindModelingModern ManMolecularMurineMusMutationNerve CellsNerve UnitNeural CellNeural Network ModelsNeural Network SimulationNeurocyteNeuronsNeurophysiology / ElectrophysiologyPathway interactionsPatientsPatternPb elementPenetrancePerceptronsPerformancePhasePhenotypePhysiopathologyPlayPrefrontal CortexPrimatesPrimates MammalsPsyche structurePsychiatric DiseasePsychiatric DisorderPsychiatryPublicationsPublishingRecording of previous eventsRodentRodentiaRodents MammalsRoleSchizophreniaSchizophrenic DisordersScientific PublicationSensationSensoryShort-Term MemorySiteSolidStructureSymptomsTechniquesTestingThalamic structureThalamusThinkingWild Type MouseWorkattentional controlbalancebalance functionbiologicbrain machine interfacecell typecognitive controlcognitive defectscognitive dysfunctioncognitive functioncognitive losscomputational modelingcomputational modelscomputational neurosciencecomputational toolboxcomputational toolscomputational toolsetcomputer based modelscomputerized modelingcomputerized toolsdata interpretationdementia praecoxdevelop therapydevelopmentalefficacy studyelectrophysiologicalexecutive controlexecutive functionexperimentexperimental researchexperimental studyexperimentsflexibilityflexiblegenome mutationheavy metal Pbheavy metal leadhistoriesimprovedinnovateinnovationinnovativeinsightintervention developmentmachine based learningmentalmental illnessmouse modelmultidisciplinarymurine modelneuralneural controlneural networkneural regulationneuromodulationneuromodulatoryneuronalneuropsychiatric diseaseneuropsychiatric disorderneuroregulationoptogeneticspathophysiologypathwayprototypepsychiatric illnesspsychological disorderpublic health relevancerecurrent neural networkschizophrenia riskschizophrenicsocial rolesuccessthalamictherapeutic targettherapeutically effectivetherapy developmentthoughtstooltreatment developmenttreatment strategywildtype mouseworking memory
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PROJECT SUMMARY (See instructions):
Cognitive flexibility, the ability to mentally switch between different thoughts and action plans, is critical for

survival in a rapidly changing environment. Impaired cognitive switching capacity is characteristic of the

cognitive inflexibility seen in multiple mental illnesses such as schizophrenia. Despite…

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