grant
Cranial Osteopathic Manipulative Medicine Enhances Brain Fluid Flow Alleviating Neuroinflammation
Organization VIRGINIA COLLEGE OF OSTEOPATHIC MEDICINELocation BLACKSBURG, UNITED STATESPosted 17 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AccountingAcquired brain injuryAcuteAdverse effectsAffectAnxietyAthletic InjuriesAutonomic nervous systemBehavioralBiologic ModelsBiologicalBiological ModelsBlood flowBody TissuesBrainBrain ConcussionBrain InjuriesBrain Nervous SystemBrain TraumaCell Communication and SignalingCell SignalingCenters for Disease ControlCenters for Disease Control and PreventionCenters for Disease Control and Prevention (U.S.)CephalicCerebral ConcussionChronicClinicalClinical DataClinical TreatmentCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalCommon Rat StrainsCommotio CerebriConvectionCoupledCranialDataDegenerative Neurologic DisordersDiffusionDiseaseDisorderDisturbance in cognitionDropsyDysfunctionEdemaEncephalonEvaluationEventExperimental DesignsFemaleFoundationsFunctional disorderHeadHealth Care UtilizationHippocampal FormationHistologicHistologicallyHydropsImage EnhancementImaging ProceduresImaging TechnicsImaging TechniquesImmuneImmunesImpaired cognitionInflammationInflammatoryInjuryIntegrative MedicineIntercellular FluidInterstitial FluidsInterventionIntracellular Communication and SignalingInvestigationKnowledgeLearningLinkLiquid substanceLymph Node Reticuloendothelial SystemLymph node properLymphatic nodesMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingManualsMeasuresMedicalMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicineMemory DeficitMemory impairmentMetabolicModel SystemModelingMolecular Biology TechniquesMotionMotor carrier accidentMusculoskeletalNCCAMNCCIHNMR ImagingNMR TomographyNational Center for Complementary and Integrative HealthNational Center for Complementary and Integrative MedicineNerve DegenerationNerve Impulse TransmissionNerve TransmissionNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurobiologyNeurodegenerative DiseasesNeurodegenerative DisordersNeurologicNeurologic DeficitNeurologic Degenerative ConditionsNeurologic DysfunctionsNeurologic ManifestationsNeurologic Signs and SymptomsNeurologic SymptomsNeurologicalNeurological ManifestationsNeurological Signs and SymptomsNeuron DegenerationNeuronal TransmissionNuclear Magnetic Resonance ImagingOsteopathicOsteopathic MedicineOsteopathyOutcomePathologicPathologyPatientsPatternPhenotypePhysiologicPhysiologicalPhysiopathologyPre-Clinical ModelPreclinical ModelsPublishingQOL improvementRatRats MammalsRattusRecoveryResearchResearch DesignRiskRodentRodentiaRodents MammalsSamplingSeriesSeveritiesSignal TransductionSignal Transduction SystemsSignalingSpinal ColumnSpineSports InjuriesStudy TypeSymptomsSystemTBI therapyTBI treatmentTechniquesThalamic structureThalamusTherapeuticTimeTissuesTraumatic Brain InjuryUnited States Centers for Disease ControlUnited States Centers for Disease Control and PreventionVertebral columnVocationZeugmatographyacute symptomalleviate symptomameliorating symptomaxon signalingaxon-glial signalingaxonal signalingbackbonebehavior studybehavioral studybiologicbiological signal transductionbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiesblast exposurebrain damagebrain parenchymabrain-injuredcholinergicchronic symptomclinical interventionclinical therapycognitive defectscognitive dysfunctioncognitive lossconcussionconcussivecontrast enhancedcytokinedecrease symptomdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdiffuseddiffusesdiffusingdiffusionsdraining lymph nodefallsfewer symptomsfluidfluid flowfunctional disabilityglia signalingglial signalinghealth care service usehealth care service utilizationimprovements in QOLimprovements in quality of lifeinjuredinjuriesinjury-related deathinnovateinnovationinnovativeintegrative healingintegrative healthliquidlymph glandlymph nodeslymphnodesmalememory dysfunctionmemory retrievalmotor vehicle accidentnerve signalingneuralneural controlneural degenerationneural inflammationneural manifestationneural regulationneural signalingneurobiologicalneurobiological mechanismneurodegenerationneurodegenerativeneurodegenerative illnessneuroinflammationneuroinflammatoryneurological degenerationneurological dysfunctionneuromodulationneuromodulatoryneuronal degenerationneuronal signalingneuropathologicneuropathologicalneuropathologyneuroregulationneurotransmissionpathophysiologypersistent symptompre-clinicalpre-clinical assessmentpreclinicalpreclinical assessmentpreventpreventingpsychologicpsychologicalpsychological distressquality of life improvementreduce symptomsregional lymph noderelieves symptomsresponsesexsoft tissuestudy designsymptom alleviationsymptom reductionsymptom reliefthalamictraumatic brain damagetraumatic brain injury therapytraumatic brain injury treatmenttreatment strategytrial regimentrial treatmentvehicular accidentwasting♀♂
Description preview
PROJECT SUMMARY/ABSTRACT
Osteopathic manipulative medicine (OMM) has been used clinically to improve the quality of life for several
medical conditions and injuries; however, limited data is available on the brain’s response to this innovative
treatment. Cranial OMM (cOMM) involves the gentle application of manual force to the head and the axial…
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