grant
COVID-19 Nsp13 Helicase Analysis: Assessment of Unwinding SARS-CoV-2 Mutagenic RNA Secondary Structures and Pharmacological Modulation in a Preclinical Model
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoVBiochemicalCOVID-19COVID-19 genomeCOVID-19 virusCOVID-19 virus genomeCOVID19 genomeCOVID19 virusCOVID19 virus genomeCV-19Cell BodyCellsCoV emergenceCoV-2CoV2ComplexCoronaviridaeCoronavirusCoronavirus Infectious Disease 2019DNA HelicasesDNA Unwinding ProteinsDNA mutationDNA unwinding enzymeEC 2.7.7.48ExonucleaseG-QuadruplexG-Quadruplexes DNAG-Quartet StructuresG-QuartetsG-TetradsG4-DNAGene TranscriptionGenetic ChangeGenetic DiversityGenetic TranscriptionGenetic VariationGenetic defectGenetic mutationGenetics-MutagenesisGenomeGenomicsIn VitroIndividualLibrariesLife CycleLife Cycle StagesMapsMiceMice MammalsModelingMolecularMouse Hepatitis CoronavirusMouse Hepatitis VirusMurineMurine Gastroenteritis VirusMurine hepatitis virusMusMutagenesisMutagenesis Molecular BiologyMutationNon-Polyadenylated RNAOrthocoronavirinaePoint MutationPre-Clinical ModelPreclinical ModelsProteinsRNARNA ExpressionRNA Gene ProductsRNA HelicaseRNA ReplicaseRNA-Dependent RNA PolymeraseRNA-Directed RNA PolymeraseRibonucleic AcidRoleSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 genomeSARS-CoV2SARS-CoV2 genomeSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2Severe Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2StructureTranscriptionTransmissionViralVirulenceVirulentVirusWuhan coronaviruscombatcorona viruscorona virus emergencecoronavirus disease 2019coronavirus disease 2019 genomecoronavirus disease 2019 viruscoronavirus disease 2019 virus genomecoronavirus disease-19coronavirus disease-19 viruscoronavirus emergencecoronavirus infectious disease-19emergent CoVemergent corona virusemergent coronavirusemerging CoVemerging corona virusemerging coronavirusgenome mutationhCoV19helicasein vivoinhibitorlife coursemurine hepatitis coronavirusnCoVnCoV2new CoVnew corona virusnew coronavirusnovel CoVnovel corona virusnovel coronavirusnucleic acid structurepharmacologicsevere acute respiratory syndrome coronavirus 2 genomesocial rolestemsymptom treatmentsymptomatic treatmenttransmission processtreat symptom
Description preview
Point mutations in the SARS-CoV-2 genome have potential consequences for the novel coronavirus life cycle, leading to alterations in its ability to replicate or transcribe its genome with an impact on transmission and virulence. Therefore, characterization of the cis- and trans-activating factors responsible for genetic variation will lead to a…
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