grant
Cortical Demyelination and Repair in Early Multiple Sclerosis.
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 1 Aug 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY202521+ years oldActivated LymphocyteActive Follow-upAdultAdult HumanAffectAreaBloodBlood Reticuloendothelial SystemBody TissuesBrainBrain Nervous SystemCNS DiseasesCNS Nervous SystemCNS disorderCell BodyCellsCentral Nervous SystemCentral Nervous System DiseasesCentral Nervous System DisordersCerebrospinal FluidChemotaxisChronicClinicalClinical Course of DiseaseClinical assessmentsCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollectionDataDegenerative Neurologic DisordersDemyelinationsDetectionDevelopmentDiseaseDisorderDisseminated SclerosisDisturbance in cognitionDysfunctionEncephalonEvaluationFe elementFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFunctional disorderFutureGeneralized GrowthGoalsGrowthImageImmuneImmune Cell ActivationImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImpaired cognitionIndividualInflammationInflammation MediatorsInflammatoryIronLanguageLeadLesionMR ImagingMR TomographyMRIMRIsMS patientMagnetic Resonance ImagingMeasuresMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedulla SpinalisMeningealMethodsMotionMotorMotor disabilityMultiple SclerosisNMR ImagingNMR TomographyNatural HistoryNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeuraxisNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeurological disabilityNewly DiagnosedNuclear Magnetic Resonance ImagingParticipantPathologyPathway interactionsPatientsPatternPb elementPersonsPhenotypePhysical assessmentPhysiopathologyPreventionProcessPrognosisProgressive DiseaseProteomicsSpinal CordT2 imagingT2 weighted imageT2 weighted imagingTestingTimeTissue GrowthTissuesUpregulationVeinsVisualizationWorkZeugmatographyactive followupadult youthadulthoodbrain MR imagingbrain MRIbrain magnetic resonance imagingbrain volumecentral nervous system demyelinating diseasecentral nervous system demyelinating disordercerebral MR imagingcerebral MRIcerebral magnetic resonance imagingcerebral spinal fluidchronic inflammatory diseasecognitive assessmentcognitive disabilitycognitive dysfunctioncognitive losscognitive testingcognitively disabledcohortdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdemyelinatedevelop therapydevelopmentaldisabilityflow cytophotometryfollow upfollow-upfollowed upfollowuphealthy volunteerheavy metal Pbheavy metal leadimage-based methodimagingimaging in vivoimaging methodimaging modalityimmune activationimprovedin vivoin vivo imaginginflammatory mediatorinsightinsular sclerosisintervention developmentlanguage impairmentmultiple sclerosis patientneurodegenerative illnessontogenypathophysiologypathwaypatients with MSpatients with multiple sclerosispeople with Multiple sclerosisphysical disabilityphysical impairmentphysically disabledphysically handicappedprospectivere-myelinatere-myelinationrecruitremyelinateremyelinationrepairrepairedspinal fluidsubstantia albatherapy developmenttranscriptomicstreatment developmentwhite matteryoung adultyoung adult ageyoung adulthood
Description preview
PROJECT SUMMARY/ABSTRACT
Multiple Sclerosis (MS) is an immune-mediated, demyelinating disorder of the central nervous system (CNS)
and a leading cause of disability in young adults. MS white matter lesions are easily visible on clinical magnetic
resonance imaging (MRI) and are the target of current treatments. However, white matter lesions are…
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