grant
Cortical Alpha-Synuclein in Dementia
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 15 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20252-photon2-photon microscopyAD dementiaAffectAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAmentiaAnatomic SitesAnatomic structuresAnatomyAttentionAutomobile DrivingAutopsyBehaviorBehavioralBehavioral ParadigmBehavioral SymptomsBrainBrain Nervous SystemBrain StemBrainstemCNS plasticityCausalityCephalicCharacteristicsCognitiveCognitive DisturbanceCognitive ImpairmentCognitive ManifestationsCognitive SymptomsCognitive declineCognitive function abnormalCorpus StriatumCorpus striatum structureCranialCuesDataDementiaDementia with Lewy BodiesDendritic SpinesDepositDepositionDiseaseDisorderDisturbance in cognitionDopamineDysfunctionElementsEncephalonEnvironmentEtiologyEventExecutive DysfunctionExecutive Function DeficitExecutive ImpairmentFunctional disorderFutureGenesGenomicsGoalsHallucinationsHeadHydroxytyramineImageImpaired cognitionImpairmentImplantIndividualLB dementiaLaboratoriesLearningLewy Body DementiaLewy Body Type Senile DementiaLewy dementiaMeasuresMediatingMicroscopyMovementNAC precursorNerve CellsNerve Transmitter SubstancesNerve UnitNeural CellNeurobehavioral ManifestationsNeurobehavioral Signs and SymptomsNeurocyteNeuronal PlasticityNeuronsNeurotransmittersOutcomePARK1 proteinPARK4 proteinPD with dementiaParalysis AgitansParkinsonParkinson DiseaseParkinson Disease dementiaParkinson's DementiaParkinson's disease with dementiaPathologicPathologyPatientsPatternPerformancePhysiopathologyPrefrontal CortexPrimary ParkinsonismPrimary Senile Degenerative DementiaProteinsPublishingResearchRiskRoleSNCASNCA proteinSecondary toSensorySpinal ColumnSpineStriate BodyStriatumSymptomsSynapsesSynapticSynaptic plasticitySystemTestingTimeTrainingVertebral columnViralVisual Hallucinationa-syna-synucleinalpha synucleinalpha synuclein genealphaSP22asynbackbonebehavior measurementbehavioral measurebehavioral measurementbody movementcausationcell cortexcentral nervous system plasticitycognitive dysfunctioncognitive losscognitive performancedementia in PDdementia in Parkinson diseasedendrite spinedensitydisease causationdrivingexcitatory neuronexperienceflexibilityflexiblefrontal cortexfrontal lobeimagingin vivoinsightinsoluble aggregatemotor symptommulti-modalitymultimodalitynecropsyneural plasticityneurobehavioral symptomneuronalneuroplasticneuroplasticitynigrostriatal systemnon A-beta component of AD amyloidnon A4 component of amyloid precursoroverexpressoverexpressionpathophysiologypostmortempostsynapticprimary degenerative dementiaprotein aggregateprotein aggregationpsychiatric symptomsenile dementia of the Alzheimer typesocial rolestriatalsymptom treatmentsymptomatic treatmentsynapsetreat symptomtwo photon excitation microscopytwo photon microscopytwo-photonα synuclein geneα-synα-synuclein
Description preview
Abstract
Lewy-Body dementias, including Parkinson’s disease Dementia and Dementia with Lewy Bodies, are
devastating, multi-system diseases and a major cause of dementia worldwide. Patients have characteristic
symptoms that suggest dysfunction of the frontal-network, including difficulty with planning, fluctuating attention
and impaired flexible…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click