grant
Correlating the microstructural thickness variations of the tear film lipid layer with clinical characteristics of dry eye with a novel optical method
Organization UNIVERSITY OF SOUTH FLORIDALocation TAMPA, UNITED STATESPosted 1 May 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025AddressAgreementAirAnteriorAreaAutoregulationBiological MarkersCharacteristicsClinicalCorneaDesiccationDessicationDevelopmentDiagnosisDiseaseDisorderDry Eye SyndromesDry eye diseaseEnvironmentExclusionEyeEyeballFilmGoalsGrantHomeostasisHumanImaging ProceduresImaging TechnicsImaging TechniquesInflammationKeratoconjunctivitis SiccaLacrimal deficiencyLaser ElectromagneticLaser RadiationLasersLeannessLinkLipidsLiteratureMeasurementMeasuresMethodsMicroscopyModern ManNational Eye InstituteNational Institutes of HealthOcular desiccationOptical MethodsPatternPhasePhysiological HomeostasisPlayPositionPositioning AttributePredispositionResearchResolutionRoleScanningSeveritiesSourceStressStructureSumSurfaceSurface TensionSusceptibilitySymptomsSystemTechniquesTestingThickThicknessThinnessUnited States National Institutes of HealthValidationVariantVariationWorkaqueousbio-markersbiologic markerbiomarkerclinical validationcornealdevelopmentaldiagnostic biomarkerdiagnostic markerdry eyeevaporationeye drynessin vivointerestmeternew diagnosticsnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation diagnosticsnext generation therapeuticsnovelnovel diagnosticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyocular drynessocular signs of drynessocular surfaceocular surface drynesspreventpreventingpsychologicpsychologicalresolutionssocial roletear deficiencyvalidations
Description preview
Project Summary
In the anterior eye, the precorneal tear film (PCTF) acts as the interface between the ocular surface and
external environment and plays a critical role in maintaining ocular surface homeostasis. In dry eye disease
(DED), the PCTF becomes thinner, and destabilizes (evaporates) rapidly leading to hyperosmolarity,
inflammation, and…
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