grant
Correlated factor models for exploratory analysis of complex multimodal study designs
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Mar 2026Deadline 31 Dec 2030
NIHUS FederalResearch GrantFY2026AD dementiaASCVDAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAtherosclerosisAtherosclerotic Cardiovascular DiseaseBiologicalBiological FunctionBiological MarkersBiological ProcessBody TissuesCOVID crisisCOVID epidemicCOVID pandemicCOVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 yearsCausalityCommunitiesComplexComputing MethodologiesDataData AnalysesData AnalysisDetectionDiseaseDisorderEnvironmentEtiologyExplosionFunctional RNAGWA studyGWASGenesHumanImageIndividualInterventionInvestigatorsLearningMachine LearningMethodsModalityModelingModern ManMolecular Dynamics SimulationMultiomic DataNoncoding RNANontranslated RNAOnset of illnessPopulationPrimary Senile Degenerative DementiaProcessRadiographyResearchResearch DesignResearch PersonnelResearchersRoentgenographySARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 pandemicSARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSevere Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 pandemicSpinalStructureStudy TypeTimeTissuesUntranslated RNAVariantVariationatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebio-markersbiologicbiologic markerbiological systemsbiomarkercausationclinical relevanceclinically relevantcohortcomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methodcoronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease pandemiccoronavirus disease-19 global pandemiccoronavirus disease-19 pandemicdata imputationdata interpretationdesigndesigningdetection platformdetection systemdisease causationdisease onsetdisorder onsetgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studyhuman diseaseimagingimmune healthimmune system healthimprovedimputation methodinsightlife spanlifespanmachine based learningmicrobiomemolecular dynamicsmulti-modalitymultimodalitymultiomicsmultiple omic datamultiple omicsneural imagingneuro-imagingneuroimagingneurological imagingnoncodingnovelpanomicsprimary degenerative dementiaprogramsradiological imagingsenile dementia of the Alzheimer typesevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicstatisticsstudy designtoolwhole genome association analysiswhole genome association study
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Project Summary/Abstract
Most human diseases are complex, manifesting from an interplay between genes and environment over the
lifespan that involve myriad biological processes. Genome-wide association studies have primarily implicated
non-coding variation that is thought to lead to disease via disruption of complex, multi-level biological…
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