grant
Coronary artery dysfunction in OSA: Role of mineralocorticoid receptors
Organization UNIVERSITY OF MISSOURI-COLUMBIALocation COLUMBIA, UNITED STATESPosted 1 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025ASCVDAccelerationAdjuvant TherapyAirAldosteroneAldosterone ReceptorAnimalsAreaAtherosclerosisAtherosclerotic Cardiovascular DiseaseBP reductionBloodBlood PressureBlood Reticuloendothelial SystemBlood VesselsBody TissuesCPAPCPAP VentilationCardiacCardiac arteryCardiac infarctionCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCell BodyCell Communication and SignalingCell SignalingCellsChronicClinical TrialsCollagen FiberContinuous Positive Airway PressureCoronaryCoronary DiseaseCoronary Vessel AnomaliesCoronary VesselsCoronary abnormalitiesCoronary anomaliesCoronary arteryCoronary artery dysfunctionCoronary dysfunctionCoronary heart diseaseDataEchocardiogramEchocardiographyEndothelial CellsEndotheliumEuthanasiaExposure toFastingFatsFatty acid glycerol estersFemaleGoalsHeartHeart VascularHeart arteryHourHumanHypertensionHypoxiaHypoxicImpairmentIncidenceInflammationIntracellular Communication and SignalingLeannessLeftLeiomyocyteLinkLipidsMediatingMercy KillingMetabolicMethodsMiceMice MammalsMicrovascular DysfunctionMineralocorticoid ReceptorModern ManMolecularMorbidityMorbidity - disease rateMurineMusMyocardial InfarctMyocardial InfarctionNon obeseNonobeseObese MiceObesityObstructive Sleep ApneaOutcomeOxidative StressOxygen DeficiencyPatientsPersonsPlacebosPlayPopulationProcessProtocolProtocols documentationReceptor ActivationReceptor InhibitionReceptor ProteinReceptor SignalingRecoveryRenin-Angiotensin-Aldosterone SystemRestRiskRoleSham TreatmentSignal TransductionSignal Transduction SystemsSignalingSingle-Nucleus SequencingSleepSleep ApneaSleep Apnea SyndromesSleep HypopneaSleep-Disordered BreathingSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellSourceSpirolactoneSpironolactoneSyndrome, Sleep Apnea, ObstructiveSystemTailTelemetriesTelemetryTestingTherapeutic InterventionThinnessTissuesTransgenic MiceTransthoracic EchocardiographyTreatment EfficacyVascular DiseasesVascular DisorderVascular Hypertensive DiseaseVascular Hypertensive DisorderVerospironeadiposityadjuvant treatmentantagonismantagonistatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebiological signal transductionblood pressure reductionblood vessel disordercardiac functioncardiac infarctcardiovascular disordercardiovascular riskcardiovascular risk factorcirculatory systemclinical significanceclinically significantcoronary artery abnormalitiescoronary artery anomaliescoronary attackcoronary disordercoronary infarctcoronary infarctioncorpulencedevelop therapydiet controldiet-associated obesitydiet-induced obesitydiet-related obesitydietary controlendothelial dysfunctionexperimentexperimental researchexperimental studyexperimentsfastedfastsfunction of the heartgene networkheart attackheart functionheart infarctheart infarctionheart sonographyhigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderimprovedimproved outcomein vivoindexinginnovateinnovationinnovativeinsightinsulin sensitivity testinsulin tolerance testinsulin-induced hypoglycemia testintervention developmentintervention efficacyintervention therapyintima medial thickeningintima-media thicknessintimal medial thickeninglower BPlower blood pressurelowers blood pressuremalemicrovascular complicationsmicrovascular diseasemortalitymouse modelmurine modelnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnormoxianovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetob/ob mouseobese individualsobese peopleobese personobese populationobese subjectspreventpreventingreceptorreduce BPreduce blood pressurereduction in BPreduction in blood pressuresNuc-Seqsexsham therapysingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsleep-related breathing disordersmall vessel diseasesnRNA sequencingsnRNA-seqsocial roletelemetrictherapeutic efficacytherapeutic targettherapy developmenttherapy efficacytreatment adherencetreatment compliancetreatment developmentvascularvascular contributionsvascular dysfunctionvasculopathy♀♂
Description preview
Abstract
Obstructive sleep apnea (OSA) is a prevalent condition worldwide, especially in people with obesity, and is an
independent risk factor for cardiovascular disease (CVD), including coronary microvascular dysfunction (CMD).
Current available OSA treatments have not consistently detected the anticipated improvements in CVD and
CMD, suggesting…
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