grant
Core F: Induced Pluripotent Stem Cell Core
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 15 Jun 2020Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2025AD dementiaAD modelAD related dementiaADRDAccelerationAged, 80 and overAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease modelAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimers DementiaAmentiaBiological MarkersBrainBrain Nervous SystemCRISPRCRISPR/Cas systemCaliforniaCandidate Disease GeneCandidate GeneCell BodyCell LineCell ReprogrammingCellLineCellsClinicalClustered Regularly Interspaced Short Palindromic RepeatsCodeCoding SystemCollaborationsCommunitiesComplexConsentControlled StudyDNA mutationDataDedicationsDementiaDevelopmentDiagnosisDown SyndromeEOADEarly Onset Alzheimer DiseaseEducation and TrainingEncephalonEthicsExhibitsFaculty EducationFaculty TrainingFibroblastsFundingGWA studyGWASGenerationsGenesGenetic ChangeGenetic DiseasesGenetic defectGenetic mutationGenetic studyGenome engineeringGoalsHomeHumanImageIndividualInvestigatorsLangdon Down syndromeLate Onset Alzheimer DiseaseMindModern ManMongolismMutationNational Institutes of HealthOldest OldParticipantPathologyPersonsPopulationPopulation HeterogeneityPostdocPostdoctoral FellowPrimary Senile Degenerative DementiaResearchResearch AssociateResearch PersonnelResearch ResourcesResearchersResourcesRiskRisk FactorsRisk-associated variantSamplingSecureSiteSkinSpecial PopulationStem Cell ResearchStrains Cell LinesStudentsStudy modelsTAR DNA binding protein 43 kDa pathologyTAR DNA binding protein 43 pathologyTAR DNA binding protein of 43 proteinopathyTDP43 associated neurodegenerationTDP43 associated neurodegenerative diseaseTDP43 associated pathologiesTDP43 induced neurodegenerationTDP43 neurodegenerationTDP43 neurodegenerative diseaseTDP43 neuropathologyTDP43 pathogenesisTDP43 pathologyTDP43 proteinopathyTDP43 related neurodegenerationTDP43 related pathologyTREM2TREM2 geneTeacher EducationTeacher EducatorTeacher PreparationTeacher Professional DevelopmentTeacher TrainingTissue SampleTrainingTraining and EducationTrans active response DNA binding protein 43 pathologyTrans active response DNA binding protein of 43 kDa proteinopathyTriggering Receptor Expressed in Myeloid Cells 2Triggering Receptor Expressed on Myeloid Cells 2Trisomy 21United States National Institutes of HealthUniversitiesValidationVariantVariationWorkalzheimer modelalzheimer riskbio-markersbiologic markerbiomarkerbrain cellcellular reprogrammingchromosome 21 trisomychromosome 21 trisomy syndromeclinical centercongenital acromicria syndromecostcultured cell linedata managementdepositorydevelopmentaldisease modeldisorder modeldiverse populationsearly onset ADearly onset Alzheimer'seducation researchethicalethnic diversityethnically diversefaculty developmentfaculty professional developmentgene editing platformgene editing systemgene editing technologygene editing toolsgene-editing toolkitgenetic conditiongenetic disordergenome mutationgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studyheterogeneous populationhomesiPSiPSCiPSCsimaginginduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinnovateinnovationinnovativeinstructor traininglate onset alzheimerlimbic-predominant age-related TDP-43 encephalopathylimbic-predominant age-related TDP43 encephalopathymorbus Downmosaicmouse modelmurine modelneuropathologicneuropathologicalneuropathologynew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynext generationnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoutreachpopulation diversitypost-docpost-doctoralpost-doctoral traineeprimary degenerative dementiaprogenitor cell modelprogenitor modelprogramspseudohypertrophic progressive muscular dystrophyracial diversityracially diverserecruitrepositoryresearch associatesrisk allelerisk generisk genotyperisk locirisk locusrisk variantsenile dementia of the Alzheimer typestem and progenitor cell modelstem cell based modelstem cell derived modelstem cell modelstem cell studyteacher developmenttrans active response DNA binding protein 43 kDa pathologytrans active response DNA binding protein 43 proteinopathytrisomy 21 syndromevalidationswhole genome association analysiswhole genome association study
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PROJECT SUMMARY - INDUCED PLURIPOTENT STEM CELL (CORE F)
Genome wide association studies (GWAS) have identified over 80 loci and candidate genes that are associated
with altered risk of developing late-onset Alzheimer’s disease (AD). Similar approaches are also increasingly
being used to identify loci associated with many other AD-Related…
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